ReviewSleep science (Sao Paulo, Brazil)
Insomnia and circadian misalignment: an underexplored interaction towards cardiometabolic risk.
Review in Sleep science (Sao Paulo, Brazil). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Long-term night shift work and cardiometabolic health in healthcare workers: a review of mechanisms and precision intervention strategies.Frontiers in public health · 2026Pooled it
- Sleep-duration abnormality, depressive symptoms, and cardiometabolic indicators: evidence from NHANES 2013-2023.Journal of cardiothoracic surgery · 2026Article
- Insomnia and Incident Cardiovascular Disease in US Hispanic/Latino Adults: Results From HCHS/SOL.Journal of the American Heart Association · 2026Article
- Trends in Sedative-Hypnotic Prescription Among Insomnia Patients: A Nationwide Cohort Study From 2010 to 2022 in Korea.Journal of Korean medical science · 2026Article
- Circadian-immune crosstalk in insomnia disorder: mechanisms and therapeutic implications.Frontiers in neuroscience · 2026Review
- The cost of high cognitive insight: chain mediation of stigma and dysfunctional sleep beliefs and attitudes in chronotype among patients with schizophrenia.Frontiers in psychiatry · 2026Article
- Chronic circadian disruption alters cardiac function and glucose regulation in mice.Npj biological timing and sleep · 2025Article
- Night Shift Work and Poor Sleep Quality Among Female Workers in Southern Brazil: A Repeated Cross-Sectional Study (2017-2022).Nature and science of sleep · 2025Article
- Application of Mendelian randomization to explore the genetic association between drinking habits of different beverages and sleep disorder.Archives of medical science : AMS · 2025Article
- Circadian rhythm of heart rate and heart rate variability in pregnancy.npj women's health · 2025Article
- Sleep disturbances are associated with greater healthcare utilization in children with autism spectrum disorder.Journal of neurodevelopmental disorders · 2024Article
- The Use of Melatoninergic Antidepressants for Stabilization of Remission in Depression Comorbid with Alcohol Abuse, Anxiety or Neuropsychiatric Disorders: A Systematic Review.Consortium psychiatricum · 2024Review
- Sleep and circadian hygiene practices association with sleep quality among Brazilian adults.Sleep medicine: X · 2023Article
- Association between social jetlag and chronic kidney disease among the Korean working population.Scientific reports · 2023Article
- Chronobiology of Parkinson's disease: Past, present and future.The European journal of neuroscience · 2023Review
- Article
- Sleepless nights mean worse metabolism: a link to cardiovascular risk in older women.European geriatric medicine · 2022Article
- Pharmacotherapeutic management of insomnia and effects on sleep processes, neural plasticity, and brain systems modulating stress: A narrative review.Frontiers in neuroscience · 2022Review
- Impact of CBTi in COMISA: Could it mean a "masking effect" of the circadian time machinery on psychosocial stress factors?Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- A Reappraisal on the Associations between Sleep-disordered Breathing, Insomnia, and Cardiometabolic Risk.American journal of respiratory and critical care medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insomnia remains the most prevalent sleep disorder worldwide, and its pathophysiology suggests an interface with circadian rhythm sleep-wake disorders (CRSWDs). Some epidemiological studies have linked insomnia and circadian misalignment with adverse cardiometabolic outcomes, but the mechanisms underlying this relationship are still unclear. The autonomic nervous system (ANS) has been pointed out as a crucial/key mediator that triggers cardiometabolic risk. Therefore, a critical review of the literature focused on the past ten years was conducted to highlight the relationship between insomnia, circadian misalignment and cardiometabolic risk, with particular emphasis on the influence of the ANS. Shift work, as a model of circadian misalignment, was shown to increase both cardiovascular and metabolic risk and so may integrate a proof of concept on this link. Furthermore, there is good evidence from previous studies supporting that cardiac autonomic dysfunction is indeed a possible mechanism that potentiates cardiometabolic risk in insomniacs and individuals with a misalignment of the circadian timing system (e.g., shift workers), via changes in autonomic variables. Further research is however required in order to definitively establish this interactive relationship.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.