Evidence map›Paper›PMID 34104310›Full record

ArticleOxidative medicine and cellular longevity2021

Antioxidant and Anti-Inflammatory Profiles of Spent Coffee Ground Extracts for the Treatment of Neurodegeneration.

Simone Angeloni, Michela Freschi, Pasquale Marrazzo, Silvana Hrelia, Daniela Beghelli, Ana Juan-García, Cristina Juan, Giovanni Caprioli, Gianni Sagratini, Cristina Angeloni

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 45 citations in OpenAlex.

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  13. Molecules (Basel, Switzerland) · 2023
    Article
  14. By-Product Extracts fromAntioxidants (Basel, Switzerland) · 2023
    Article
  15. Article
  16. Agri-Food Wastes as Natural Source of Bioactive Antioxidants.Antioxidants (Basel, Switzerland) · 2023
    Article
  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Simone AngeloniSchool of Pharmacy, University of Camerino, Via Sant' Agostino 1, I-62032 Camerino (MC), Italy.
Michela FreschiDepartment for Life Quality Studies, Alma Mater Studiorum University of Bologna, Rimini 47921, Italy.
Pasquale MarrazzoDepartment for Life Quality Studies, Alma Mater Studiorum University of Bologna, Rimini 47921, Italy.
Silvana HreliaDepartment for Life Quality Studies, Alma Mater Studiorum University of Bologna, Rimini 47921, Italy.
Daniela BeghelliSchool of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032 Camerino (MC), Italy.ORCID https://orcid.org/0000-0002-4935-7874
Ana Juan-GarcíaLaboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés Estellés s/n, 46100 Burjassot, València, Spain.
Cristina JuanLaboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés Estellés s/n, 46100 Burjassot, València, Spain.
Giovanni CaprioliSchool of Pharmacy, University of Camerino, Via Sant' Agostino 1, I-62032 Camerino (MC), Italy.
Gianni SagratiniSchool of Pharmacy, University of Camerino, Via Sant' Agostino 1, I-62032 Camerino (MC), Italy.
Cristina AngeloniSchool of Pharmacy, University of Camerino, Via Sant' Agostino 1, I-62032 Camerino (MC), Italy.ORCID https://orcid.org/0000-0002-6731-6187
Università di Camerino · ITUniversity of Bologna · ITUniversitat de València · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spent coffee grounds (SCGs), waste products of coffee beverage production, are rich in organic compounds such as phenols. Different studies have demonstrated phenol beneficial effects in counteracting neurodegenerative diseases. These diseases are associated with oxidative stress and neuroinflammation, which initiates the degeneration of neurons by overactivating microglia. Unfortunately, to date, there are no pharmacological therapies to treat these pathologies. The aim of this study was to evaluate the phenolic content of 4 different SCG extracts and their ability to counteract oxidative stress and neuroinflammation. Caffeine and 5-

Indexed as

Anti-Inflammatory AgentsAntioxidantsCoffeeHumansNervous System DiseasesPlant ExtractsAnti-Inflammatory AgentsAntioxidantsCoffeePlant Extracts

Identifiers

PMID34104310
PMCPMC8159652
OpenAlexW3163861685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.