Evidence map›Paper›PMID 34104245›Full record

ArticleJournal of medicine and life

Neurological complications in COVID-19 - a diagnostic challenge.

Vitalie Vacaras, Sorina Frunze, Adrian Mihai Cordos

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicine and life. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Vitalie VacarasNeurology Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Sorina FrunzeNeurology Department, Cluj-Napoca County Emergency Hospital, Cluj-Napoca, Romania.
Adrian Mihai CordosNeurology Department, Cluj-Napoca County Emergency Hospital, Cluj-Napoca, Romania.
Iuliu Hațieganu University of Medicine and Pharmacy · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the exponential growth of COVID-19 cases, the neurological complications reported during or after the infection became more common. There is limited knowledge regarding the pathophysiological mechanisms that are responsible for these complications. Recent data provides compelling evidence for the neurotropic nature of SARS-CoV-2, based on neurological manifestations reported during the current pandemic, as well as on previous experience with other coronaviruses. We present the case of a patient who developed headaches, motor deficit and dysphasia after respiratory COVID-19. Imaging tests showed heterogeneous central nervous system lesions (multiple subarachnoid hemorrhages and two ischemic strokes). Given the plethora of atypical neurological complications of COVID-19 described in the current literature, establishing a positive diagnosis and deciding on a treatment plan proved to be particularly challenging. We set to discuss some of the possible pathologies, hypothesized to be associated with COVID-19, that could lead to concomitant neurological lesions, similar to those noticed in our patient.

Indexed as

Antibodies, ViralComputed Tomography AngiographyCOVID-19HumansMagnetic Resonance ImagingMaleMiddle AgedNervous System DiseasesPandemicsSARS-CoV-2ThoraxTomography, X-Ray ComputedAntibodies, ViralACE2 – angiotensin converting enzyme IIBBB – blood-brain barrierBMI – body mass indexBP – blood pressurecardiovascular medicineCNS – central nervous systemCOVID-19COVID-19 – coronavirus diseaseCRP – C-reactive proteinCSF – cerebrospinal fluidCTA – Computer tomography angiographyCT – Computer tomographyCVT – cerebral venous thrombosisECG – electrocardiogramHolter ECG – Holter electrocardiogramHR – heart rateI.V. – intravenousLMWH – low molecular weight heparinMRA – Magnetic resonance angiographyMRC scale – Medical Research Council's scaleMRI – Magnetic resonance imagingneurologyPACNS – primary angiitis of the central nervous systemPCA – posterior cerebral arteryPCoA – posterior communicating arteryPCR – polymerase chain reactionRCVS – reversible cerebral vasoconstriction syndromeRR – reference rangeRT-PCR – real-time polymerase chain reactionSAH – subarachnoid hemorrhageSARS-CoV-2 – severe acute respiratory syndrome coronavirus 2strokesubarachnoid hemorrhageUL – upper limit

Identifiers

PMID34104245
PMCPMC8169143
OpenAlexW3171255158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.