Evidence map›Paper›PMID 34104078›Full record

ArticleInternational journal of medical sciences2021

Immune checkpoint molecules are regulated by transforming growth factor (TGF)-

Ritu Shrestha, Kim R Bridle, Darrell H G Crawford, Aparna Jayachandran

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ritu ShresthaFaculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Kim R BridleFaculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Darrell H G CrawfordFaculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Aparna JayachandranFaculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Greenslopes Private Hospital · AUUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer with a high mortality rate. Epithelial-to-mesenchymal transition (EMT) confers cancer cells with immune evasive ability by modulating the expression of immune checkpoints in many cancers. Thus, the aim of our study is to examine the interplay between EMT and immune checkpoint molecules in HCC. A reversible EMT model was utilised with transforming growth factor (TGF)-

Indexed as

B7 AntigensB7-H1 AntigenCarcinoma, HepatocellularCell Line, TumorEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansLiver NeoplasmsSignal TransductionTransforming Growth Factor beta1Up-RegulationB7 AntigensB7-H1 AntigenCD274 protein, humanCD276 protein, humanTGFB1 protein, humanTransforming Growth Factor beta1epithelial-to-mesenchymal transitionhepatocellular carcinomaimmune checkpoint moleculestransforming growth factor-β1

Identifiers

PMID34104078
PMCPMC8176170
OpenAlexW3157047407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.