Evidence map›Paper›PMID 34103904›Full record

ArticleClinical interventions in aging2021

Molecular Biomarkers Associated with Early-Onset Symptomatic Intracranial Atherosclerosis.

Yunfang Luo, Fang Yu, Xianjing Feng, Di Liao, Yuanlin Ying, Xi Li, Qin Huang, Zeyu Liu, Minping Wei, Tingting Zhao and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical interventions in aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Yunfang Luo *Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Fang Yu *Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Xianjing FengDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Di LiaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Yuanlin YingDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Xi LiDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.ORCID 0000-0002-9601-5076
Qin HuangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Zeyu LiuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Minping WeiDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Tingting ZhaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Lin ZhangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Ruxin TuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.ORCID 0000-0003-1379-4201
Jian XiaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePrevious studies have shown a rising incidence of early-onset symptomatic intracranial atherosclerosis (sICAS), which has brought a severe economic burden to social development. This study aimed to evaluate the molecular biomarkers associated with early-onset sICAS and to seek possible intervention strategies for early prevention. PATIENTS AND

methodsWe consecutively recruited patients with sICAS and divided them into two groups based on age: early-onset sICAS group as age ≤60 years old and late-onset sICAS group as age >60 years old. We collected and compared the demographic data and laboratory results of each group. A bivariate logistic regression model was applied to evaluate the independent molecular biomarkers of early-onset sICAS.

resultsA total of 1007 subjects with sICAS were enrolled in this study, comprising 519 patients in the early-onset sICAS group and 488 patients in the late-onset sICAS group. Bivariate logistic regression analysis demonstrated an increased level of white blood cell, platelet, albumin globulin ratio, free triiodothyronine, and a decreased level of total bile acid, urea nitrogen, high-density lipoprotein, homocysteine, and fibrinogen in the early-onset sICAS group when compared to the late-onset group.

conclusionOur study showed the relevance between early sICAS and circulating levels of different molecular biomarkers. Detection of these related molecular biomarkers may provide a simple way for early sICAS preventions in the future.

Indexed as

AgedApolipoprotein A-IApolipoproteins BBiomarkersBrain IschemiaCase-Control StudiesC-Reactive ProteinFibrinogenHumansIntracranial ArteriosclerosisMaleMiddle AgedRisk FactorsStrokeTriglyceridesApolipoprotein A-IApolipoproteins BBiomarkersC-Reactive ProteinFibrinogenTriglyceridesischemic strokemolecular biomarkerssymptomatic intracranial atherosclerosis

Identifiers

PMID34103904
PMCPMC8179742
OpenAlexW3171710710

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.