Evidence map›Paper›PMID 34103707›Full record

Trial reportGenes and immunity2021

Association between ABO and Duffy blood types and circulating chemokines and cytokines.

Sarah C Van Alsten, John G Aversa, Loredana Santo, M Constanza Camargo, Troy Kemp, Jia Liu, Wen-Yi Huang, Joshua Sampson, Charles S Rabkin

Open access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Genes and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. The highest Duffy (Health science reports · 2023
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Sarah C Van AlstenDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-2131-6939
John G AversaSurgical Oncology Program, Center for Cancer Research, NCI, Bethesda, MD, USA.
Loredana SantoOccupational and Environmental Epidemiology Branch, DCEG, NCI, Bethesda, MD, USA.
M Constanza CamargoMetabolic Epidemiology Branch, DCEG, NCI, Bethesda, MD, USA.
Troy KempHPV Immunology Laboratory, Frederick National Laboratory for Cancer Research, NCI, Frederick, MD, USA.
Jia LiuCancer Genomics Research Laboratory, DCEG, NCI, Bethesda, MD, USA.
Wen-Yi HuangMetabolic Epidemiology Branch, DCEG, NCI, Bethesda, MD, USA.
Joshua SampsonBiostatistics Branch, DCEG, NCI, Bethesda, MD, USA.
Charles S RabkinInfections and Immunoepidemiology Branch, DCEG, NCI, Bethesda, MD, USA. rabkinc@mail.nih.gov.ORCID http://orcid.org/0000-0002-0053-3806
Center for Cancer Research · USFrederick National Laboratory for Cancer Research · USNational Institutes of Health · USUniversity of North Carolina at Chapel Hill · US

Funding

Molecular mechanisms of infection-related cancerZIACP010212 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ENGELS, ERIC A · 2010 to 2025
$4.6M
6 · The paper itself

Abstract

Blood group antigens are inherited traits that may play a role in immune and inflammatory processes. We investigated associations between blood groups and circulating inflammation-related molecules in 3537 non-Hispanic white participants selected from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Whole-genome scans were used to infer blood types for 12 common antigen systems based on well-characterized single-nucleotide polymorphisms. Serum levels of 96 biomarkers were measured on multiplex fluorescent bead-based panels. We estimated marker associations with blood type using weighted linear or logistic regression models adjusted for age, sex, smoking status, and principal components of population substructure. Bonferroni correction was used to control for multiple comparisons, with two-sided p values < 0.05 considered statistically significant. Among the 1152 associations tested, 10 were statistically significant. Duffy blood type was associated with levels of CXCL6/GCP2, CXCL5/ENA78, CCL11/EOTAXIN, CXCL1/GRO, CCL2/MCP1, CCL13/MCP4, and CCL17/TARC, whereas ABO blood type was associated with levels of sVEGFR2, sVEGFR3, and sGP130. Post hoc pairwise t-tests showed that individuals with type Fy(a+b-) had the lowest mean levels of all Duffy-associated markers, while individuals with type A blood had the lowest mean levels of all ABO-associated markers. Additional work is warranted to explore potential clinical implications of these differences.

Indexed as

Blood Group AntigensCytokinesBiomarkersChemokinesHumansInflammationLogistic ModelsMaleBiomarkersBlood Group AntigensChemokinesCytokines

Identifiers

PMID34103707
PMCPMC8185309
OpenAlexW3169845822

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.