ArticleCommunications biology2021
Placental secretome characterization identifies candidates for pregnancy complications.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The trial behind it
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Placental TRPV2 supports trophoblast function and normal fetal development.Nature communications · 2026Article
- Placental Steroid Hormones in Preeclampsia: Multilayered Regulation of Endocrine Pathogenesis.Endocrine reviews · 2026Review
- Trimester-specific reference intervals for serum N-acetyl-β-D-glucosaminidase in healthy pregnant women in Hainan, China.European journal of obstetrics & gynecology and reproductive biology: X · 2026Article
- Placental mTOR signalling links mitochondrial dysfunction, nutrient transport and neonatal beta cell perturbations in mice.Diabetologia · 2025Article
- Placenta-Derived Proteins in Preeclampsia: A Human In Vivo Study.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Placental endocrine function is controlled by maternal gut Bifidobacterium in germ-free mice.Journal of translational medicine · 2025Article
- Placental mitochondrial calcium uniporter modulates offspring susceptibility to metabolic dysfunction.Molecular metabolism · 2025Article
- Oxidised Apolipoprotein Peptidome Characterises Metabolic Dysfunction-Associated Steatotic Liver Disease.Liver international : official journal of the International Association for the Study of the Liver · 2025Article
- Gestational Diabetes Mellitus: Mechanisms Underlying Maternal and Fetal Complications.Endocrinology and metabolism (Seoul, Korea) · 2025Review
- Overexpression of Igf2-derived Mir483 inhibits Igf1 expression and leads to developmental growth restriction and metabolic dysfunction in mice.Cell reports · 2024Article
- Nanoparticles Dysregulate the Human Placental Secretome with Consequences on Angiogenesis and Vascularization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Editorial: Developmental biology and endocrine research for a successful pregnancy.Frontiers in endocrinology · 2024Article
- RISING STARS: Mechanistic insights into maternal-fetal cross talk and islet beta-cell development.The Journal of endocrinology · 2023Review
- The Effects of Combined Exposure to Bisphenols and Perfluoroalkyls on Human Perinatal Stem Cells and the Potential Implications for Health Outcomes.International journal of molecular sciences · 2023Article
- Extracellular Matrix Influences Gene Expression and Differentiation of Mouse Trophoblast Stem Cells.Stem cells and development · 2023Article
- Fetal manipulation of maternal metabolism is a critical function of the imprinted Igf2 gene.Cell metabolism · 2023Article
- Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age.Frontiers in endocrinology · 2023Article
- Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice†.Biology of reproduction · 2022Article
- Identification of Structural and Molecular Signatures Mediating Adaptive Changes in the Mouse Kidney in Response to Pregnancy.International journal of molecular sciences · 2022Article
- Sex differences in the intergenerational inheritance of metabolic traits.Nature metabolism · 2022Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Alterations in maternal physiological adaptation during pregnancy lead to complications, including abnormal birthweight and gestational diabetes. Maternal adaptations are driven by placental hormones, although the full identity of these is lacking. This study unbiasedly characterized the secretory output of mouse placental endocrine cells and examined whether these data could identify placental hormones important for determining pregnancy outcome in humans. Secretome and cell peptidome analyses were performed on cultured primary trophoblast and fluorescence-activated sorted endocrine trophoblasts from mice and a placental secretome map was generated. Proteins secreted from the placenta were detectable in the circulation of mice and showed a higher relative abundance in pregnancy. Bioinformatic analyses showed that placental secretome proteins are involved in metabolic, immune and growth modulation, are largely expressed by human placenta and several are dysregulated in pregnancy complications. Moreover, proof-of-concept studies found that secreted placental proteins (sFLT1/MIF and ANGPT2/MIF ratios) were increased in women prior to diagnosis of gestational diabetes. Thus, placental secretome analysis could lead to the identification of new placental biomarkers of pregnancy complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.