ArticleScientific reports2021
Defensive freezing and its relation to approach-avoidance decision-making under threat.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- High-fat diet exposure, internal state, and reward value influence decision making during motivational conflict.Neurobiology of stress · 2026Article
- Exposure to false cardiac feedback alters pain perception and anticipatory cardiac frequency.eLife · 2026Article
- A novel approach-avoidance task to study decision making under outcome uncertainty.Psychonomic bulletin & review · 2026Article
- How Temporal Predictability of Threat and Action Preparation Affect Defensive Freezing Responses.Psychophysiology · 2026Article
- Overcoming Automatic Behavioral Tendencies in Approach-Avoidance Conflict Decisions.Psychophysiology · 2025Article
- Dorsal hippocampus represents locations to avoid as well as locations to approach during approach-avoidance conflict.PLoS biology · 2025Article
- How Distributed Subcortical Integration of Reward and Threat May Inform Subsequent Approach-Avoidance Decisions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Social threat avoidance depends on action-outcome predictability.Communications psychology · 2024Article
- Pupil dilation reflects effortful action invigoration in overcoming aversive Pavlovian biases.Cognitive, affective & behavioral neuroscience · 2024Article
- The neurocomputational link between defensive cardiac states and approach-avoidance arbitration under threat.Communications biology · 2024Article
- Dorsal hippocampus represents locations to avoid as well as locations to approach during approach-avoidance conflict.bioRxiv : the preprint server for biology · 2024Article
- The influence of aggressive exercise on responses to self-perceived and others' pain.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Neural patterns of threat response in adolescents predict vulnerability for and resilience against internalizing symptoms during COVID-19 waves.Neuroimage. Reports · 2023Article
- The nature and neurobiology of fear and anxiety: State of the science and opportunities for accelerating discovery.Neuroscience and biobehavioral reviews · 2023Review
- Reply to 'Post-encounter freezing during approach-avoidance conflict: the role of the hippocampus'.Nature reviews. Neuroscience · 2023Article
- Exploring hazard anticipation and stress while driving in light of defensive behavior theory.Scientific reports · 2023Article
- Quantifying aberrant approach-avoidance conflict in psychopathology: A review of computational approaches.Neuroscience and biobehavioral reviews · 2023Review
- Validation of the neuroconnective endophenotype questionnaire (NEQ): a new clinical tool for medicine and psychiatry resulting from the contribution of Ehlers-Danlos syndrome.Frontiers in medicine · 2023Article
- Spontaneous instrumental avoidance learning in social contexts.Scientific reports · 2022Article
- Freezing revisited: coordinated autonomic and central optimization of threat coping.Nature reviews. Neuroscience · 2022Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Successful responding to acutely threatening situations requires adequate approach-avoidance decisions. However, it is unclear how threat-induced states-like freezing-related bradycardia-impact the weighing of the potential outcomes of such value-based decisions. Insight into the underlying computations is essential, not only to improve our models of decision-making but also to improve interventions for maladaptive decisions, for instance in anxiety patients and first-responders who frequently have to make decisions under acute threat. Forty-two participants made passive and active approach-avoidance decisions under threat-of-shock when confronted with mixed outcome-prospects (i.e., varying money and shock amounts). Choice behavior was best predicted by a model including individual action-tendencies and bradycardia, beyond the subjective value of the outcome. Moreover, threat-related bradycardia (high-vs-low threat) interacted with subjective value, depending on the action-context (passive-vs-active). Specifically, in action-contexts incongruent with participants' intrinsic action-tendencies, stronger bradycardia related to diminished effects of subjective value on choice across participants. These findings illustrate the relevance of testing approach-avoidance decisions in relatively ecologically valid conditions of acute and primarily reinforced threat. These mechanistic insights into approach-avoidance conflict-resolution may inspire biofeedback-related techniques to optimize decision-making under threat. Critically, the findings demonstrate the relevance of incorporating internal psychophysiological states and external action-contexts into models of approach-avoidance decision-making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.