Trial reportNature communications2021
A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech.
Trial report in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 67 citations in OpenAlex.
- Unilateral inferior olivary hypertrophy in a patient with primary progressive apraxia of speech.Neuroimage. Reports · 2026Article
- Unifying Divergent Conceptions in Nonfluent/Agrammatic and Semantic Primary Progressive Aphasia.Brain sciences · 2026Review
- Frontotemporal dementia: does structural MRI-based clustering match clinical syndromes?Frontiers in neuroscience · 2026Article
- Distinct and shared multimodal neuroimaging patterns in clinical frontotemporal dementia syndromes.Brain communications · 2026Article
- Behavioral Variant Frontotemporal Dementia in the Context of Progressive Apraxia of Speech: A Clinico-Neuroimaging Case-Control Study.Brain sciences · 2025Article
- Cause of death for patients who present with primary progressive apraxia of speech.Parkinsonism & related disorders · 2025Article
- Pick's disease presenting as progressive apraxia of speech: Atypical clinical and neuroimaging features in three autopsy-confirmed cases.Clinical neurology and neurosurgery · 2025Article
- Uncovering Image-Driven Subtypes with Distinct Pathology and Clinical Course in Autopsy-Confirmed Four Repeat Tauopathies.Annals of neurology · 2025Article
- Clinicopathological and Neuroimaging Correlates of Disease Duration in Primary Progressive Apraxia of Speech.European journal of neurology · 2025Article
- A Review of FDG-PET in Progressive Supranuclear Palsy and Corticobasal Syndrome.International journal of molecular sciences · 2025Review
- Distinct 11C-ER176 PET Neuroinflammatory Profiles and Tau Colocalization in Progressive Apraxia of Speech With and Without Parkinson-plus Syndrome.Clinical nuclear medicine · 2025Article
- Dysphagia and Mortality Risk in Individuals With Primary Progressive Apraxia of Speech.Annals of clinical and translational neurology · 2025Article
- High-definition brain stimulation targeting separate regions leads to differential word retrieval outcomes in patients with primary progressive aphasia: a pilot study.Frontiers in neurology · 2025Article
- Progression of Motor Speech Function in Speakers With Primary Progressive Apraxia of Speech.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Apraxia phenotypes and frontotemporal lobar degeneration.Journal of neurology · 2024Article
- Automatic Speech Recognition in Primary Progressive Apraxia of Speech.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Clinicopathologic and Neuroimaging Correlations of Nonverbal Oral Apraxia in Patients With Neurodegenerative Disease.Neurology · 2024Article
- Incidence of Primary Progressive Apraxia of Speech and Primary Progressive Aphasia in Olmsted County, MN, 2011-2022.Neurology · 2024Article
- Clinicoradiological and neuropathological evaluation of primary progressive aphasia.Journal of neurology, neurosurgery, and psychiatry · 2024Article
- The yes-no reversal phenomenon in patients with primary progressive apraxia of speech.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
Corrections and comments
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Authors and funding
29 authors at 7 institutions in 2 countries.
Funding
Abstract
Progressive apraxia of speech is a neurodegenerative syndrome affecting spoken communication. Molecular pathology, biochemistry, genetics, and longitudinal imaging were investigated in 32 autopsy-confirmed patients with progressive apraxia of speech who were followed over 10 years. Corticobasal degeneration and progressive supranuclear palsy (4R-tauopathies) were the most common underlying pathologies. Perceptually distinct speech characteristics, combined with age-at-onset, predicted specific 4R-tauopathy; phonetic subtype and younger age predicted corticobasal degeneration, and prosodic subtype and older age predicted progressive supranuclear palsy. Phonetic and prosodic subtypes showed differing relationships within the cortico-striato-pallido-nigro-luysial network. Biochemical analysis revealed no distinct differences in aggregated 4R-tau while tau H1 haplotype frequency (69%) was lower compared to 1000+ autopsy-confirmed 4R-tauopathies. Corticobasal degeneration patients had faster rates of decline, greater cortical degeneration, and shorter illness duration than progressive supranuclear palsy. These findings help define the pathobiology of progressive apraxia of speech and may have consequences for development of 4R-tau targeting treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.