ArticleNature communications2021
Heteromeric HSFA2/HSFA3 complexes drive transcriptional memory after heat stress in Arabidopsis.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 2 of them syntheses that pooled it.
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Who cites it
106 citing papers in PubMed, 2 syntheses or guidelines pooled it, 249 citations in OpenAlex.
- Acetylation as a dynamic regulatory interface between plant stress memory, cross-tolerance, and crop resilience design.Frontiers in plant science · 2026Pooled it
- Genome-wide transcriptional analysis of rapeseed (Brassica napus L.) responses to heat stress: an integrated RNA-Seq meta-analysis, gene co-expression, and gene regulatory network study.BMC plant biology · 2025Pooled it
- A Heat-Inducible Rubisco Activase Safeguards Photosynthesis via Multilevel Regulation and Dual Function.Plant biotechnology journal · 2026Article
- Genome-wide analysis of the HSF gene family in lily and functional characterization of LdHSFC1 under heat stress.Plant cell reports · 2026Article
- Reproductive thermotolerance: from flower development to seed initiation.The New phytologist · 2026Review
- Unravelling Mechanisms of Acquired Drought Tolerance by Priming in Tomato Using Integrative Multi-Omics Phenotypic Analysis.Plant biotechnology journal · 2026Article
- Principles and mechanisms of plant acclimation to heat stress.Nature reviews. Molecular cell biology · 2026Review
- Harnessing genomics approaches for heat stress resilience in wheat: from discovery to deployment.Journal of experimental botany · 2026Review
- The SlDREBA4-SlASIL2 module mediates tomato thermotolerance by regulating the expression of SlHSP20/90.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Dynamic regulation of proteostasis underlies thermopriming-mediated acquired thermotolerance in Arabidopsis.Plant communications · 2026Article
- Adaptive response to long-term high temperatures during the reproductive development in Arabidopsis thaliana.Planta · 2026Article
- Physiological Responses, Molecular Basis, and Integrated Regulation of Heat Tolerance in Soybean.Plants (Basel, Switzerland) · 2026Review
- MaHSFA2c modulates high temperature-inhibited chlorophyll breakdown in banana fruit by directly inducing the transcription of the E3 ligase gene MaBAH1.Molecular horticulture · 2026Article
- Natural variation uncouples HSFA2 induction from volatile-induced thermotolerance in Arabidopsis thaliana.Plant molecular biology · 2026Article
- Integrative cross-platform transcriptomic analysis coupled with machine learning identifies candidate biomarkers of abiotic stress resilience in Arabidopsis thaliana.BMC plant biology · 2026Article
- Membrane stability under heat stress: molecular signaling, lipid remodeling, and defense mechanisms in plants.Plant cell reports · 2026Review
- Epigenetic modifications in plant abiotic stress adaptation: towards climate-resilient and sustainable crop improvement.Frontiers in plant science · 2026Review
- Integrated transcriptomic and metabolomic analyses reveal biphasic thermal adaptation strategies inPeerJ · 2026Article
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46 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adaptive plasticity in stress responses is a key element of plant survival strategies. For instance, moderate heat stress (HS) primes a plant to acquire thermotolerance, which allows subsequent survival of more severe HS conditions. Acquired thermotolerance is actively maintained over several days (HS memory) and involves the sustained induction of memory-related genes. Here we show that FORGETTER3/ HEAT SHOCK TRANSCRIPTION FACTOR A3 (FGT3/HSFA3) is specifically required for physiological HS memory and maintaining high memory-gene expression during the days following a HS exposure. HSFA3 mediates HS memory by direct transcriptional activation of memory-related genes after return to normal growth temperatures. HSFA3 binds HSFA2, and in vivo both proteins form heteromeric complexes with additional HSFs. Our results indicate that only complexes containing both HSFA2 and HSFA3 efficiently promote transcriptional memory by positively influencing histone H3 lysine 4 (H3K4) hyper-methylation. In summary, our work defines the major HSF complex controlling transcriptional memory and elucidates the in vivo dynamics of HSF complexes during somatic stress memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.