ArticleNature communications2021
Optimizing vaccine allocation for COVID-19 vaccines shows the potential role of single-dose vaccination.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 2 of them syntheses that pooled it.
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Who cites it
84 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Predictive models for health outcomes due to SARS-CoV-2, including the effect of vaccination: a systematic review.Systematic reviews · 2024Pooled it
- Associations between COVID-19 infection and sex steroid hormones.Frontiers in endocrinology · 2022Pooled it
- Optimizing infectious disease mitigation under dynamic conditions.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A mixture cure modeling framework for survival analysis of hospitalized COVID-19 patients: implications for hospital resource management.BMC medical informatics and decision making · 2026Article
- Modeling the impact of vaccine dose prioritization strategies during the 2022 mpox outbreak.American journal of epidemiology · 2026Article
- Article
- A generalized SEIRW-VN framework for modeling infectious disease dynamics.Scientific reports · 2026Article
- Optimal deployment of limited vaccine supplies to control mpox outbreaks.NPJ vaccines · 2025Article
- Article
- Review
- Machine learning insights on the effectiveness of non-pharmaceutical interventions against COVID-19 in Nigeria.International health · 2025Article
- Hotspot model shows how location-based superspreading accelerates and reshapes epidemics.PNAS nexus · 2025Article
- Avoiding four fallacies in the fair allocation of influenza countermeasures.BMJ global health · 2025Article
- Beyond the Pandemic Era: Recent Advances and Efficacy of SARS-CoV-2 Vaccines Against Emerging Variants of Concern.Vaccines · 2025Review
- Vaccine failure mode determines population-level impact of vaccination campaigns during epidemics.Journal of the Royal Society, Interface · 2025Article
- Protect or prevent? A practicable framework for the dilemmas of COVID-19 vaccine prioritization.PloS one · 2025Article
- Learning from the COVID-19 pandemic: A systematic review of mathematical vaccine prioritization models.Infectious Disease Modelling · 2024Review
- Learning from the COVID-19 pandemic: a systematic review of mathematical vaccine prioritization models.medRxiv : the preprint server for health sciences · 2024Article
- Vaccination and its impact on healthcare utilization in two groups of vaccinated and unvaccinated patients with COVID-19: A cross-sectional study in Iran between 2021 and 2022.Health science reports · 2024Article
- Covid19Vaxplorer: A free, online, user-friendly COVID-19 vaccine allocation comparison tool.PLOS global public health · 2024Article
24 more citing papers are in PubMed but not listed here.
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7 authors.
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Abstract
Most COVID-19 vaccines require two doses, however with limited vaccine supply, policymakers are considering single-dose vaccination as an alternative strategy. Using a mathematical model combined with optimization algorithms, we determined optimal allocation strategies with one and two doses of vaccine under various degrees of viral transmission. Under low transmission, we show that the optimal allocation of vaccine vitally depends on the single-dose efficacy. With high single-dose efficacy, single-dose vaccination is optimal, preventing up to 22% more deaths than a strategy prioritizing two-dose vaccination for older adults. With low or moderate single-dose efficacy, mixed vaccination campaigns with complete coverage of older adults are optimal. However, with modest or high transmission, vaccinating older adults first with two doses is best, preventing up to 41% more deaths than a single-dose vaccination given across all adult populations. Our work suggests that it is imperative to determine the efficacy and durability of single-dose vaccines, as mixed or single-dose vaccination campaigns may have the potential to contain the pandemic much more quickly.
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