Evidence map›Paper›PMID 34103494›Full record

ArticleNature communications2021

Maternal iron deficiency perturbs embryonic cardiovascular development in mice.

Jacinta I Kalisch-Smith, Nikita Ved, Dorota Szumska, Jacob Munro, Michael Troup, Shelley E Harris, Helena Rodriguez-Caro, Aimée Jacquemot, Jack J Miller, Eleanor M Stuart and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
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  7. Article
  8. Article
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  11. Article
  12. Article
  13. Article
  14. Feto-placental blood vessel development.Development (Cambridge, England) · 2025
    Review
  15. Review
  16. Why cells need iron: a compendium of iron utilisation.Trends in endocrinology and metabolism: TEM · 2024
    Review
  17. Review
  18. Article
  19. Review
  20. Molecular Pathways and Animal Models of Truncus Arteriosus.Advances in experimental medicine and biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 3 countries.

Jacinta I Kalisch-SmithDepartment of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-5071-3805
Nikita VedDepartment of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford, Oxford, UK.
Dorota SzumskaDepartment of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford, Oxford, UK.
Jacob MunroVictor Chang Cardiac Research Institute, Molecular, Structural and Computational Biology Division, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-2751-0989
Michael TroupVictor Chang Cardiac Research Institute, Molecular, Structural and Computational Biology Division, Sydney, NSW, Australia.
Shelley E HarrisDepartment of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford, Oxford, UK.
Helena Rodriguez-CaroDepartment of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford, Oxford, UK.
Aimée JacquemotDepartment of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford, Oxford, UK.
Jack J MillerDepartment of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-6258-1299
Eleanor M StuartDepartment of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford, Oxford, UK.
Magda WolnaDepartment of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford, Oxford, UK.
Emily HardmanHeart Development Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-3073-0309
Fabrice PrinHeart Development Laboratory, The Francis Crick Institute, London, UK.
Eva Lana-ElolaImmune Cell Biology and Down Syndrome Laboratory, The Francis Crick Institute, London, UK.
Rifdat AoidiImmune Cell Biology and Down Syndrome Laboratory, The Francis Crick Institute, London, UK.
Elizabeth M C FisherInstitute of Neurology, University College London, London, UK.ORCID http://orcid.org/0000-0003-2850-9936
Victor L J TybulewiczImmune Cell Biology and Down Syndrome Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-2439-0798
Timothy J MohunHeart Development Laboratory, The Francis Crick Institute, London, UK.
Samira Lakhal-LittletonDepartment of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford, Oxford, UK.
Sarah De ValDepartment of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford, Oxford, UK.
Eleni GiannoulatouVictor Chang Cardiac Research Institute, Molecular, Structural and Computational Biology Division, Sydney, NSW, Australia.
Duncan B SparrowDepartment of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford, Oxford, UK. duncan.sparrow@dpag.ox.ac.uk.ORCID http://orcid.org/0000-0002-1141-6613
University of Oxford · GBThe Francis Crick Institute · GBVictor Chang Cardiac Research Institute · AUAarhus University · DKEaling Hospital · GBUniversity College London · GBUniversity of Cambridge · GB

Funding

British Heart Foundation FS/12/63/29895British Heart Foundation FS/17/35/32929British Heart Foundation FS/17/55/33100British Heart Foundation RE/13/1/30181British Heart Foundation RE/18/3/34214Cancer Research UK FC001117Cancer Research UK FC001157Medical Research Council FC001117Medical Research Council FC001157Medical Research Council MR/S01019X/1Medical Research Council U117562103Wellcome Trust 090532/Z/09/ZWellcome Trust 091911/B/10/ZWellcome Trust 098327Wellcome Trust 098328Wellcome Trust 107457/Z/15/ZWellcome Trust FC001117Wellcome Trust FC001157Wellcome Trust FC001194
6 · The paper itself

Abstract

Congenital heart disease (CHD) is the most common class of human birth defects, with a prevalence of 0.9% of births. However, two-thirds of cases have an unknown cause, and many of these are thought to be caused by in utero exposure to environmental teratogens. Here we identify a potential teratogen causing CHD in mice: maternal iron deficiency (ID). We show that maternal ID in mice causes severe cardiovascular defects in the offspring. These defects likely arise from increased retinoic acid signalling in ID embryos. The defects can be prevented by iron administration in early pregnancy. It has also been proposed that teratogen exposure may potentiate the effects of genetic predisposition to CHD through gene-environment interaction. Here we show that maternal ID increases the severity of heart and craniofacial defects in a mouse model of Down syndrome. It will be important to understand if the effects of maternal ID seen here in mice may have clinical implications for women.

Indexed as

Iron DeficienciesAnimalsAorta, ThoracicBiomarkersCardiovascular SystemCell DifferentiationCoronary VesselsDietary SupplementsEdemaEmbryo, MammalianEmbryonic DevelopmentFemaleGene-Environment InteractionGene Expression ProfilingGreen Fluorescent ProteinsIronBiomarkersGreen Fluorescent ProteinsIronTretinoin

Identifiers

PMID34103494
PMCPMC8187484
OpenAlexW3167499432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.