ArticleScience translational medicine2021
Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro.
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In one paragraph
Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 2 pooled it
12.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
72 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Systemic cytokines drive conserved severity-associated myeloid responses across bacterial and viral infections.Communications biology · 2025Pooled it
- Early peripheral blood MCEMP1 and HLA-DRA expression predicts COVID-19 prognosis.EBioMedicine · 2023Pooled it
- Spleen tyrosine kinase inhibition restores myeloid homeostasis in COVID-19.Science advances · 2023Trial
- Monocytes in pneumonia: Functional plasticity and innate memory (Review).International journal of molecular medicine · 2026Review
- A whole-blood cryopreservation method streamlines clinical sample collection for multimodal single-cell immune profiling in sepsis.JCI insight · 2026Article
- Ferroptosis-Senescence Crosstalk in Sepsis-Associated Acute Lung Injury: Mechanisms and Therapeutic Opportunities.Biomedicines · 2026Review
- Dysregulated myelopoiesis and enhanced glutaminase-dependent neutrophil survival in preclinical obesity.ImmunoHorizons · 2026Article
- Scoring gene importance by interpreting single-cell foundation models.Nature biotechnology · 2026Article
- Article
- Longitudinal peripheral blood immune profiling reveals dynamic changes of five major immune cell lineages and their clinical associations in pediatric scrub typhus.Frontiers in immunology · 2026Article
- Article
- Interleukin-39 aggravates sepsis by inducing self-sustaining neutrophil activation in the lungs via the CXCL1-CXCR2 pathway.International journal of biological sciences · 2026Article
- Single-Cell transcriptomic profiles of peripheral blood immune cells reveal early monocyte and platelet activation in the transition from high-risk states to clinical sepsis.Scientific reports · 2025Article
- Beyond Negative Regulation: IL-1R8 and IL-1R2 as Novel Immune Checkpoints.European journal of immunology · 2025Review
- The cellular substrate of evolutionary novelty.Current biology : CB · 2025Review
- Monocyte-macrophage membrane expression of IL-1R2 is a severity biomarker in sepsis.Cell death & disease · 2025Article
- Application of Human Plasma/Serum to Cell Culture In Vitro: A Translational Research Approach to Better Define Disease Mechanisms.Clinical and translational science · 2025Review
- Article
- Decoding immune low-response states in sepsis: single-cell and 3D spatial transcriptomic insights into immunoparalysis.Frontiers in immunology · 2025Review
- From Defense to Dysfunction: Decoding the Paradox of Emergency Granulopoiesis in Sepsis Pathogenesis.Research (Washington, D.C.) · 2025Review
12 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
18 authors at 3 institutions in 1 country.
Miguel ReyesBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-2776-0862
Michael R FilbinBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-2588-7504
Roby P BhattacharyyaBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-6955-5088
Abraham SonnyDepartment of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2101-9849
Arnav MehtaBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-0313-2848
Kianna BillmanBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-5675-3309
Kyle R KaysDepartment of Emergency Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Mayra Pinilla-VeraDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Maura E BensonDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5481-4638
Lisa A CosimiDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5269-1881
Deborah T HungBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-4262-0673
Bruce D LevyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9515-5731
Alexandra-Chloe VillaniBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-7461-0408
Moshe Sade-FeldmanBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-0022-0287
Rebecca M BaronDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1673-9523
Marcia B GoldbergBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-4266-9733
Paul C BlaineyBroad Institute of MIT and Harvard, Cambridge, MA, USA. pblainey@broadinstitute.org nhacohen@broadinstitute.org.ORCID 0000-0002-4889-8783
Nir HacohenBroad Institute of MIT and Harvard, Cambridge, MA, USA. pblainey@broadinstitute.org nhacohen@broadinstitute.org.ORCID 0000-0002-2349-2656
Broad Institute · USBrigham and Women's Hospital · USHarvard University · US
Funding
Virology CoreU19AI082630 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG, GEORG Michael LAUER · 2009 to 2026
$48.1MResearch Training for AnesthetistsT32GM007592 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI STUART A FORMAN · 1985 to 2026
$11.8MSingle-cell genomic profiling to identify immune signatures of bacterial sepsis in humansR01AI153142 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI FILBIN, MICHAEL, GOLDBERG, MARCIA B · 2021 to 2025
$5.0MTherapeutic modulation of zinc for lung injury and mechanobiologyR01HL142093 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BARON, REBECCA M, TSCHUMPERLIN, DANIEL J. · 2019 to 2022
$2.8MThe Immune Cell Atlas â A Robust Framework to Map the Entire Human Immune SystemR56AI137244 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BENOIST, CHRISTOPHE O., HACOHEN, NIR · 2018 to 2018
$2.0MLow-input multiplex isolation and profiling of human immune cell subsets using an integrated microfluidics deviceU24AI118668 · NIAID · BROAD INSTITUTE, INC. · PI HACOHEN, NIR · 2015 to 2019
$2.0MBioinformatic and functional analysis of antibiotic-responsive small non-coding RNAs in bacterial pathogensK08AI119157 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI BHATTACHARYYA, ROBY PAUL · 2015 to 2018
$758kNIAID NIH HHS K08 AI119157NIAID NIH HHS R01 AI153142NIAID NIH HHS R56 AI137244NIAID NIH HHS U19 AI082630NIAID NIH HHS U24 AI118668NIGMS NIH HHS T32 GM007592NIH HHS 1K08 AI119157-04
Abstract
Bacterial sepsis and severe COVID-19 share similar clinical manifestations and are both associated with dysregulation of the myeloid cell compartment. We previously reported an expanded CD14
Indexed as
COVID-19Hematopoietic Stem Cell TransplantationSepsisHumansMyeloid CellsSARS-CoV-2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.