Evidence map›Paper›PMID 34103370›Full record

Observational studyImmunoHorizons2021

Aging- and Tumor-Mediated Increase in CD8

Wei X Huff, Marpe Bam, Jack M Shireman, Jae Hyun Kwon, Leo Song, Sharlé Newman, Aaron A Cohen-Gadol, Scott Shapiro, Tamara Jones, Kelsey Fulton and 5 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in ImmunoHorizons, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  20. CD8International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Wei X HuffDepartment of Neurosurgery, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indiana, IN.
Marpe BamDepartment of Neurosurgery, University of Wisconsin School of Medicine and Public Health, Madison, WI; and.
Jack M ShiremanDepartment of Neurosurgery, University of Wisconsin School of Medicine and Public Health, Madison, WI; and.ORCID 0000-0002-5088-7805
Jae Hyun KwonDepartment of Neurosurgery, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indiana, IN.ORCID 0000-0001-6113-8888
Leo SongDepartment of Neurosurgery, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indiana, IN.ORCID 0000-0002-1366-2594
Sharlé NewmanDepartment of Neurosurgery, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indiana, IN.ORCID 0000-0003-2153-3044
Aaron A Cohen-GadolDepartment of Neurosurgery, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indiana, IN.ORCID 0000-0002-4946-1524
Scott ShapiroDepartment of Neurosurgery, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indiana, IN.
Tamara JonesDepartment of Medical and Molecular Genetics, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indiana, IN.
Kelsey FultonDepartment of Medical and Molecular Genetics, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indiana, IN.ORCID 0000-0003-4943-5614
Sheng LiuDepartment of Medical and Molecular Genetics, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indiana, IN.
Hiromi TanakaDepartment of Medical and Molecular Genetics, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indiana, IN.ORCID 0000-0002-7897-2606
Yunlong LiuDepartment of Medical and Molecular Genetics, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indiana, IN.
Jun WanDepartment of Medical and Molecular Genetics, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indiana, IN.ORCID 0000-0001-9286-6562
Mahua DeyDepartment of Neurosurgery, University of Wisconsin School of Medicine and Public Health, Madison, WI; and dey@neurosurgery.wisc.edu.ORCID 0000-0002-7024-5164
Indiana University · USUniversity of Wisconsin–Madison · US

Funding

Plasmacytoid Dendritic Cells in Malignant GliomaK08NS092895 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI DEY, MAHUA · 2016 to 2020
$917k
NINDS NIH HHS K08 NS092895
6 · The paper itself

Abstract

Clinical use of various forms of immunotherapeutic drugs in glioblastoma (GBM), has highlighted severe T cell dysfunction such as exhaustion in GBM patients. However, reversing T cell exhaustion using immune checkpoint inhibitors in GBM clinical trials has not shown significant overall survival benefit. Phenotypically, CD8

Indexed as

AdultAgedAged, 80 and overAgingBrain NeoplasmsCD28 AntigensCD8-Positive T-LymphocytesCellular SenescenceDrug Resistance, NeoplasmFemaleGlioblastomaHumansImmune Checkpoint InhibitorsImmunophenotypingLymphocyte ActivationLymphocytes, Tumor-InfiltratingCD28 AntigensImmune Checkpoint Inhibitors

Identifiers

PMID34103370
PMCPMC8591704
OpenAlexW3167066150

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.