Evidence map›Paper›PMID 34103255›Full record

ArticleClinical breast cancer2021

Rates of Ipsilateral Local-regional Recurrence in High-risk Patients Undergoing Immediate Post-mastectomy Reconstruction (AFT-01).

Christina M Dudley, Alyssa A Wiener, Trista J Stankowski-Drengler, Jessica R Schumacher, Amanda B Francescatti, Samuel O Poore, Caprice C Greenberg, Heather B Neuman

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical breast cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02171078 (Post-Treatment Surveillance in Breast Cancer), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02171078 completednot on this map

Post-Treatment Surveillance in Breast Cancer: Bringing Cost Effectiveness Research (CER) to the Alliance

TypeobservationalSponsorUniversity of Wisconsin, MadisonRan2014 to 2017Enrolled34,359ConditionsBreast Neoplasms
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Article
  4. Contrast-Enhanced Chest Computed Tomography forDiagnostics (Basel, Switzerland) · 2025
    Article
  5. Observational
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Christina M DudleySchool of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.
Alyssa A WienerWisconsin Surgical Outcomes Research Program, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Trista J Stankowski-DrenglerWisconsin Surgical Outcomes Research Program, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Jessica R SchumacherWisconsin Surgical Outcomes Research Program, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Amanda B FrancescattiACS Clinical Research Program, American College of Surgeons, Chicago, IL.
Samuel O PooreUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI; Division of Plastic Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Caprice C GreenbergWisconsin Surgical Outcomes Research Program, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI; University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI; Division of Plastic Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Heather B NeumanWisconsin Surgical Outcomes Research Program, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI; University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI; Division of Plastic Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI. Electronic address: neuman@surgery.wisc.edu.
University of Wisconsin–Madison · USAmerican College of Surgeons · USUniversity of Wisconsin Carbone Cancer Center · US

Funding

Member Site CoreU10CA180821 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI Evanthia Galanis · 2014 to 2026
$177.3M
UW Surgical Oncology Research Training Program (UW-SORT)T32CA090217 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Muhammed Murtaza, Heather B Neuman · 2001 to 2026
$8.3M
BUILDING INTERDISCIPLINARY RESEARCH CAREER IN WOMEN'S HEALTH (BIRCWH) SCHOLARSK12HD055894 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI BURNSIDE, ELIZABETH S · 2007 to 2016
$4.1M
Clinical Academic Oncologist Training ProgramK12CA087718 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI ALBERTINI, MARK R · 2000 to 2008
$3.8M
NCI NIH HHS K12 CA087718NCI NIH HHS T32 CA090217NCI NIH HHS U10 CA180821NICHD NIH HHS K12 HD055894
6 · The paper itself

Abstract

backgroundSome surgeons remain hesitant to perform immediate breast reconstruction (IBR) in patients with higher risk cancers owing to concerns about cancer recurrence and/or detection. Our objective was to determine the rate of ipsilateral local-regional recurrence for stage II/III patients who underwent IBR.

methodsThe National Cancer Database special study mechanism was used to create a stratified sample of women diagnosed with stage II/III breast cancer from 1217 facilities. Demographic, tumor, and recurrence data for women who underwent mastectomy with or without IBR were abstracted, including location of recurrence and method of detection. Estimates of 5-year local-regional recurrence rates were calculated and factors associated with recurrence were identified with multivariable Cox regression.

resultsSome 13% (692/5318) of stage II/III patients underwent IBR after mastectomy. Patients undergoing IBR were younger (P < .001), with fewer comorbid conditions (P < .001), and with lower tumor burden in the breast (P = .001) and the lymph nodes (P = 0.01). The 5-year rate of ipsilateral local-regional recurrence was 3.6% with no significant difference between patients with or without IBR (3.0% vs. 3.7%, P = .4). Most recurrences were detected by the patient (45%) or on physician examination (24%). Reconstruction was not associated with recurrence on multivariable analysis (hazard ratio = 0.83, P = .52).

conclusionWomen with stage II/III breast cancer selected for IBR had similar rates of ipsilateral local-regional recurrence compared with those undergoing mastectomy alone. Offering IBR after mastectomy in a patient-centered manner to select patients with stage II/III breast cancer is an acceptable consideration.

Indexed as

AdultBreast NeoplasmsDisease-Free SurvivalFemaleFollow-Up StudiesHumansMastectomyMiddle AgedNeoplasm Recurrence, LocalRisk Factorsbreast cancerCancer outcomesLocally-advancedReconstructionRecurrence

Identifiers

PMID34103255
PMCPMC8881795
OpenAlexW3142736835

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.