ArticleBMC plant biology2021
Investigation of long non-coding RNAs as regulatory players of grapevine response to powdery and downy mildew infection.
Article in BMC plant biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Blast Resistance Gene Pish Derived Reprogramming of Noncoding RNAs in Rice.Rice (New York, N.Y.) · 2026Article
- Analysis of Non-Coding RNAs and N6-Methyladenosine-Modified Genes in Response to flg22 in Grape Immunity.Plant biotechnology journal · 2025Article
- Genome-wide identification and functional prediction of long non-coding RNAs in plastic growth iniScience · 2025Article
- Review of the Pathogenic Mechanism of Grape Downy Mildew (Microorganisms · 2025Review
- Functional divergence of LncRNAs in wheat-fungal interactions: insights from stem rust-responsive wheat transcriptomes.Physiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- Epigenetic weapons of plants against fungal pathogens.BMC plant biology · 2024Review
- Genome-wide association analysis identifies a consistent QTL for powdery mildew resistance on chromosome 3A in Nordic and Baltic spring wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Comparative evaluation of physiological and molecular responses of blackcurrant varieties to powdery mildew infection.Frontiers in plant science · 2024Article
- Emphasizing the Role of Long Non-Coding RNAs (lncRNA), Circular RNA (circRNA), and Micropeptides (miPs) in Plant Biotic Stress Tolerance.Plants (Basel, Switzerland) · 2023Review
- Genomic survey of high-throughput RNA-Seq data implicates involvement of long intergenic non-coding RNAs (lincRNAs) in cytoplasmic male-sterility and fertility restoration in pigeon pea.Genes & genomics · 2023Article
- Roles of long non-coding RNAs in plant immunity.PLoS pathogens · 2023Review
- Identification of Pseudo-R genes in Vitis vinifera and characterization of their role as immunomodulators in host-pathogen interactions.Journal of advanced research · 2022Article
- Long Non-Coding RNAs as Emerging Regulators of Pathogen Response in Plants.Non-coding RNA · 2022Review
- Editorial: Functional analysis of species-specific non-coding RNAs in plants.Frontiers in genetics · 2022Article
- Molecular mechanisms underlying multi-level defense responses of horticultural crops to fungal pathogens.Horticulture research · 2022Article
- Genome-Wide Identification of Powdery Mildew Responsive Long Non-Coding RNAs inFrontiers in genetics · 2022Article
- Epigenetic regulation and beyond in grapevine-pathogen interactions: a biotechnological perspective.Physiologia plantarumReview
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong non-coding RNAs (lncRNAs) are regulatory transcripts of length > 200 nt. Owing to the rapidly progressing RNA-sequencing technologies, lncRNAs are emerging as considerable nodes in the plant antifungal defense networks. Therefore, we investigated their role in Vitis vinifera (grapevine) in response to obligate biotrophic fungal phytopathogens, Erysiphe necator (powdery mildew, PM) and Plasmopara viticola (downy mildew, DM), which impose huge agro-economic burden on grape-growers worldwide.
resultsUsing computational approach based on RNA-seq data, 71 PM- and 83 DM-responsive V. vinifera lncRNAs were identified and comprehensively examined for their putative functional roles in plant defense response. V. vinifera protein coding sequences (CDS) were also profiled based on expression levels, and 1037 PM-responsive and 670 DM-responsive CDS were identified. Next, co-expression analysis-based functional annotation revealed their association with gene ontology (GO) terms for 'response to stress', 'response to biotic stimulus', 'immune system process', etc. Further investigation based on analysis of domains, enzyme classification, pathways enrichment, transcription factors (TFs), interactions with microRNAs (miRNAs), and real-time quantitative PCR of lncRNAs and co-expressing CDS pairs suggested their involvement in modulation of basal and specific defense responses such as: Ca
conclusionsOverall, the identified lncRNAs provide insights into the underlying intricacy of grapevine transcriptional reprogramming/post-transcriptional regulation to delay or seize the living cell-dependent pathogen growth. Therefore, in addition to defense-responsive genes such as TFs, the identified lncRNAs can be further examined and leveraged to candidates for biotechnological improvement/breeding to enhance fungal stress resistance in this susceptible fruit crop of economic and nutritional importance.
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