Evidence map›Paper›PMID 34102973›Full record

ArticleCurrent Alzheimer research2021

Codonopsis pilosula Polysaccharides Alleviate Aβ

Yi R Hu, San L Xing, Chuan Chen, Ding Z Shen, Jiu L Chen

Abstract read
In one paragraph

Article in Current Alzheimer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. International journal of molecular sciences · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. International journal of molecular sciences · 2025
    Article
  6. Improvement on mitochondrial energy metabolism ofFrontiers in pharmacology · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yi R HuShanghai Geriatric Institute of Chinese Medicine, Shanghai 200031, China.
San L XingShanghai Geriatric Institute of Chinese Medicine, Shanghai 200031, China.
Chuan ChenShanghai Geriatric Institute of Chinese Medicine, Shanghai 200031, China.
Ding Z ShenShanghai Geriatric Institute of Chinese Medicine, Shanghai 200031, China.
Jiu L ChenShanghai Geriatric Institute of Chinese Medicine, Shanghai 200031, China.

Funding

National Natural Science Foundation of China 81503626Shanghai Municipal Health Commission Fund 2020JP020, (2018-2020)-CCCK-4004
6 · The paper itself

Abstract

backgroundAlzheimer's disease (AD) is the most common type of dementia and has a complex pathogenesis with no effective treatment. Energy metabolism disorders, as an early pathological event of AD,have attracted attention as a promising area of AD research. Codonopsis pilosula Polysaccharides are the main effective components of Codonopsis pilosula, which have been demonstrated to regulate energy metabolism.

methodsIn order to further study the roles and mechanisms of Codonopsis pilosula polysaccharides in AD, this study used an Aβ

resultsThe results showed that Aβ

conclusionOur findings reveal that Codonopsis pilosula polysaccharides protected PC12 cells from Aβ

Indexed as

NADAmyloid beta-PeptidesAnimalsCodonopsisEnergy MetabolismHumansPC12 CellsPeptide FragmentsPlant ExtractsPolysaccharidesRatsSignal TransductionAmyloid beta-Peptidesamyloid beta-protein (1-40)NADPeptide FragmentsPlant ExtractsPolysaccharidesAlzheimer's diseaseCD38Codonopsis pilosula polysaccharideEnergy dysmetabolismNAD+neurofibrillary tangles.

Identifiers

PMID34102973
PMCPMC8506921

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.