Evidence map›Paper›PMID 34102856›Full record

Observational studyJournal of the American Heart Association2021

Mapping Cerebrovascular Reactivity Impairment in Patients With Symptomatic Unilateral Carotid Artery Disease.

Martina Sebök, Christiaan Hendrik Bas van Niftrik, Sebastian Winklhofer, Susanne Wegener, Giuseppe Esposito, Christoph Stippich, Andreas Luft, Luca Regli, Jorn Fierstra

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Observational
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Martina SebökDepartment of Neurosurgery University Hospital ZurichUniversity of Zurich Switzerland.
Christiaan Hendrik Bas van NiftrikDepartment of Neurosurgery University Hospital ZurichUniversity of Zurich Switzerland.
Sebastian WinklhoferClinical Neuroscience Center University Hospital ZurichUniversity of Zurich Switzerland.
Susanne WegenerClinical Neuroscience Center University Hospital ZurichUniversity of Zurich Switzerland.
Giuseppe EspositoDepartment of Neurosurgery University Hospital ZurichUniversity of Zurich Switzerland.
Christoph StippichClinical Neuroscience Center University Hospital ZurichUniversity of Zurich Switzerland.
Andreas LuftClinical Neuroscience Center University Hospital ZurichUniversity of Zurich Switzerland.
Luca RegliDepartment of Neurosurgery University Hospital ZurichUniversity of Zurich Switzerland.
Jorn FierstraDepartment of Neurosurgery University Hospital ZurichUniversity of Zurich Switzerland.
University of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Comprehensive hemodynamic impairment mapping using blood oxygenation-level dependent (BOLD) cerebrovascular reactivity (CVR) can be used to identify hemodynamically relevant symptomatic unilateral carotid artery disease. Methods and Results This prospective cohort study was conducted between February 2015 and July 2020 at the Clinical Neuroscience Center of the University Hospital Zurich, Zurich, Switzerland. One hundred two patients with newly diagnosed symptomatic unilateral internal carotid artery (ICA) occlusion or with 70% to 99% ICA stenosis were included. An age-matched healthy cohort of 12 subjects underwent an identical BOLD functional magnetic resonance imaging examination. Using BOLD functional magnetic resonance imaging with a standardized CO

Indexed as

Cerebrovascular CirculationDiffusion Magnetic Resonance ImagingHemodynamicsPerfusion ImagingAgedBrain InfarctionCarotid Artery, InternalCarotid StenosisCase-Control StudiesFemaleHumansMaleMiddle AgedPredictive Value of TestsProspective StudiesSwitzerlandBOLD‐CVRhemodynamicICA occlusionICA stenosisischemic infarct

Identifiers

PMID34102856
PMCPMC8477889
OpenAlexW3168872836

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.