Evidence map›Paper›PMID 34102760›Full record

ArticleJournal of stroke2021

Stroke Recurrence in First-Ever Symptomatic Carotid Web: A Cohort Study.

Stephane Olindo, Nicolas Chausson, Aissatou Signate, Sylvie Mecharles, Jean-Luc Hennequin, Martine Saint-Vil, Mireille Edimonana-Kaptue, Severine Jeannin, Anne Landais, Philippe Cabre and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Journal of stroke, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Safety and efficacy of staged bilateral carotid artery stenting for bilateral carotid webs.Journal of cerebrovascular and endovascular neurosurgery · 2026
    Article
  3. Article
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  5. Article
  6. Cerebrovascular fibromuscular dysplasia.Therapeutic advances in neurological disorders · 2026
    Review
  7. Comparative analysis of stenting for carotid web and atherosclerotic disease.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  8. Article
  9. Status epilepticus of carotid web after carotid artery stenting: A case report.The Journal of international medical research · 2025
    Article
  10. Article
  11. Article
  12. Outcomes after carotid revascularization for symptomatic carotid artery web: A multi-institutional cohort study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Stephane OlindoStroke Unit, Bordeaux University Hospital, Bordeaux, France.
Nicolas ChaussonNeurology Department, Sud-Francilien Hospital, Corbeil-Essonnes, France.
Aissatou SignateNeurology Department, Martinique University Hospital, Martinique.
Sylvie MecharlesNeurology Department, Guadeloupe University Hospital, Guadeloupe.
Jean-Luc HennequinVascular Surgery Department, Martinique University Hospital, Martinique.
Martine Saint-VilNeurology Department, Martinique University Hospital, Martinique.
Mireille Edimonana-KaptueNeurology Department, Martinique University Hospital, Martinique.
Severine JeanninNeurology Department, Martinique University Hospital, Martinique.
Anne LandaisNeurology Department, Guadeloupe University Hospital, Guadeloupe.
Philippe CabreNeurology Department, Martinique University Hospital, Martinique.
Igor SibonStroke Unit, Bordeaux University Hospital, Bordeaux, France.
Didier SmadjaNeurology Department, Sud-Francilien Hospital, Corbeil-Essonnes, France.
Julien JouxNeurology Department, Martinique University Hospital, Martinique.
Centre Hospitalier Universitaire de Martinique · MQBordeaux Population Health · FRCentre Hospitalier Sud Francilien · FRInstitut Pasteur de la Guadeloupe · GP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeCarotid web (CaW) is an intimal variant of fibromuscular dysplasia responsible for ipsilateral cerebral ischemic events (CIE). Symptomatic CaW likely has a high risk of recurrent CIE, but no salient prospective data are available. We aimed to assess recurrence rate and its predictors after a first-ever CIE.

methodsConsecutive Afro-Caribbean patients who had cryptogenic first-ever CIEs (ischemic stroke [IS] or transient ischemic attack [TIA]) associated with ipsilateral CaW were included in this multicenter observational cohort study. The follow-up (January 2008 to March 2019) focused on CIE recurrences. Kaplan-Meier method assessed rates of recurrences and Cox proportional hazards regression analyzed risk factors.

resultsNinety-two patients (79 first-ever ISs and 13 TIAs; mean age±standard deviation, 49.8±9.9 years; 52 [56.5%] women) were included. During a mean follow-up of 50.5±29.6 months, 19 (20.7%) patients experienced recurrent ipsilateral CIEs (16 ISs and three TIAs). Of 23 patients receiving surgery/stenting treatment, no recurrence occurred after the intervention (median follow-up, 39.8 months [interquartile range, 27.6 to 72.4]). Under medical treatment alone, the annual recurrent CIE rate was 6.9%, and the cumulative rate was 4.4% at 30-day, 10.8% at 1-year, 19.8% at 2-year, 23.2% at 3-year, and 27.3% at 5-year. Presence of silent cerebral infarctions was the only independent risk factor of CIE recurrences (hazard ratio, 6.99; 95% confidence interval, 2.4 to 20.4; P=0.004).

conclusionsUnder medical treatment alone, symptomatic CaW was associated with a high rate of recurrence that reached 27.3% at 5-year. Surgery/stenting seems to be efficient, and randomized control trials are required to confirm the benefit of these interventions.

Indexed as

Carotid arteryCarribbean regionCohort studiesFibromuscular dysplasiaIschemic strokeRecurrence

Identifiers

PMID34102760
PMCPMC8189848
OpenAlexW3166794011

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.