ArticleJournal of stroke2021
Decreased Basal Ganglia Volume in Cerebral Amyloid Angiopathy.
Article in Journal of stroke, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Subcortical gray matter atrophy and iron deposition in patients with vascular dementia: a multimodal MRI study.Frontiers in neuroscience · 2026Article
- Apolipoprotein E Alleles and Motor Signs in Older Adults with Alzheimer's Dementia.International journal of molecular sciences · 2025Article
- Cerebral Amyloid Angiopathy Is Associated With Higher RAnnals of clinical and translational neurology · 2025Article
- Relationship between cerebrospinal fluid circulation markers, brain degeneration, and cognitive impairment in cerebral amyloid angiopathy.Frontiers in aging neuroscience · 2025Article
- Subcortical volumes and cognition in CADASIL - A pilot study.Cerebral circulation - cognition and behavior · 2024Article
- Subcortical volumes in cerebral amyloid angiopathy compared with Alzheimer's disease and controls.Frontiers in neuroscience · 2023Article
- Cerebellar atrophy and its implications on gait in cerebral amyloid angiopathy.Journal of neurology, neurosurgery, and psychiatry · 2022Article
- The vascular risk factors and vascular neuropathology in subjects with autopsy-confirmed dementia with Lewy bodies.International journal of geriatric psychiatry · 2022Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 3 countries.
Funding
Abstract
background and purposeCerebral amyloid angiopathy (CAA) is a common pathology of the leptomeningeal and cortical small vessels associated with hemorrhagic and non-hemorrhagic brain injury. Given previous evidence for CAA-related loss of cortical thickness and white matter volume, we hypothesized that CAA might also cause tissue loss in the basal ganglia.
methodsWe compared basal ganglia volumes expressed as a percentage of total intracranial volume (pBGV) of non-demented patients with sporadic and hereditary CAA to age-matched healthy control (HC) and Alzheimer's disease (AD) cohorts.
resultsPatients with sporadic CAA had lower pBGV (n=80, 1.16%±0.14%) compared to HC (n=80, 1.30%±0.13%, P<0.0001) and AD patients (n=80, 1.23%±0.11%, P=0.001). Similarly, patients with hereditary CAA demonstrated lower pBGV (n=25, 1.26%±0.17%) compared to their matched HC (n=25, 1.36%±0.15%, P=0.036). Using a measurement of normalized basal ganglia width developed for analysis of clinical-grade magnetic resonance images, we found smaller basal ganglia width in patients with CAA-related lobar intracerebral hemorrhage (ICH; n=93, 12.35±1.47) compared to age-matched patients with hypertension-related deep ICH (n=93, 13.46±1.51, P<0.0001) or HC (n=93, 15.45±1.22, P<0.0001). Within the sporadic CAA research cohort, decreased basal ganglia volume was independently correlated with greater cortical gray matter atrophy (r=0.45, P<0.0001), increased basal ganglia fractional anisotropy (r=-0.36, P=0.001), and worse performance on language processing (r=0.35, P=0.003), but not with cognitive tests of executive function or processing speed.
conclusionsThese findings suggest an independent effect of CAA on basal ganglia tissue loss, indicating a novel mechanism for CAA-related brain injury and neurologic dysfunction.
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