Evidence map›Paper›PMID 34102755›Full record

ReviewJournal of stroke2021

Management of Patients with Asymptomatic Carotid Stenosis May Need to Be Individualized: A Multidisciplinary Call for Action.

Kosmas I Paraskevas, Dimitri P Mikhailidis, Hediyeh Baradaran, Alun H Davies, Hans-Henning Eckstein, Gianluca Faggioli, Jose Fernandes E Fernandes, Ajay Gupta, Mateja K Jezovnik, Stavros K Kakkos and 17 more

Open access · diamondAbstract readReview
In one paragraph

Review in Journal of stroke, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Cerebral pulse oximetry in carotid endarterectomy: an impact study.Revista da Associacao Medica Brasileira (1992) · 2025
    Article
  4. Comparison of Endarterectomy and Stenting in the Treatment of Carotid Artery Stenosis: A Real-World Nationwide, Total Population-Based Study from Korea.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2025
    Article
  5. Review
  6. The burden of carotid-related strokes.Annals of translational medicine · 2022
    Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 20 institutions in 11 countries.

Kosmas I ParaskevasDepartment of Vascular Surgery, Central Clinic of Athens, Athens, Greece.
Dimitri P MikhailidisDepartment of Clinical Biochemistry, Royal Free Hospital Campus, University College London Medical School, University College London (UCL), London, UK.
Hediyeh BaradaranDepartment of Radiology, University of Utah, Salt Lake City, UT, USA.
Alun H DaviesSection of Vascular Surgery, Imperial College & Imperial Healthcare NHS Trust, London, UK.
Hans-Henning EcksteinDepartment of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Gianluca FaggioliVascular Surgery, University of Bologna "Alma Mater Studiorum", Policlinico S. Orsola Malpighi, Bologna, Italy.
Jose Fernandes E FernandesDepartment of Vascular Surgery, University of Lisbon, Lisbon Academic Medical Center, Lisbon, Portugal.
Ajay GuptaDepartment of Radiology, Weill Cornell Medicine, New York, NY, USA.
Mateja K JezovnikDepartment of Advanced Cardiopulmonary Therapies and Transplantation, The University of Texas Health Science Centre at Houston, Houston, TX, USA.
Stavros K KakkosDepartment of Vascular Surgery, University of Patras Medical School, Patras, Greece.
Niki KatsikiFirst Department of Internal Medicine, AHEPA University Hospital, Thessaloniki, Greece.
M Eline KooiCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands.
Gaetano LanzaVascular Surgery Department, IRCSS MultiMedica Hospital, Castellanza, Italy.
Christos D LiapisAthens Vascular Research Center, Athens, Greece.
Ian M LoftusSt. George's Vascular Institute, St. George's University London, London, UK.
Antoine MillonDepartment of Vascular and Endovascular Surgery, Louis Pradel Hospital, Hospices Civils de Lyon, France.
Andrew N NicolaidesDepartment of Surgery, University of Nicosia Medical School, Nicosia, Cyprus.
Pavel PoredosDepartment of Vascular Disease, University Medical Centre Ljubljana, Slovenia.
Rodolfo PiniVascular Surgery, University of Bologna "Alma Mater Studiorum", Policlinico S. Orsola Malpighi, Bologna, Italy.
Jean-Baptiste RiccoDepartment of Clinical Research, University of Poitiers, CHU de Poitiers, Poitiers, France.
Tatjana RundekDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Luca SabaDepartment of Radiology, Azienda Ospedaliera Universitaria Di Cagliari, Cagliari, Italy.
Francesco SpinelliVascular Surgery Division, Campus Bio-Medico University of Rome, Rome, Italy.
Francesco StiloVascular Surgery Division, Campus Bio-Medico University of Rome, Rome, Italy.
Sherif SultanWestern Vascular Institute, Department of Vascular and Endovascular Surgery, University Hospital Galway, National University of Ireland, Galway, Ireland.
Clark J ZeebregtsDivision of Vascular Surgery, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Seemant ChaturvediDepartment of Neurology & Stroke Program, University of Maryland School of Medicine, Baltimore, MD, USA.
Università Campus Bio-Medico · ITAHEPA University Hospital · GRAthens Medical Center · GRAzienda Ospedaliero-Universitaria Cagliari · ITHospices Civils de Lyon · FRImperial College Healthcare NHS Trust · GBLjubljana University Medical Centre · SIMaastricht University · NLMultiMedica · ITOllscoil na Gaillimhe – University of Galway · IEPoliclinico S.Orsola-Malpighi · ITSt George's, University of London · GBTechnical University of Munich · DEUniversité de Poitiers · FRUniversity College London · GBUniversity Medical Center Groningen · NLUniversity of Bologna · ITUniversity of Lisbon · PTUniversity of Maryland, Baltimore · USUniversity of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The optimal management of patients with asymptomatic carotid stenosis (ACS) is the subject of extensive debate. According to the 2017 European Society for Vascular Surgery guidelines, carotid endarterectomy should (Class IIa; Level of Evidence: B) or carotid artery stenting may be considered (Class IIb; Level of Evidence: B) in the presence of one or more clinical/imaging characteristics that may be associated with an increased risk of late ipsilateral stroke (e.g., silent embolic infarcts on brain computed tomography/magnetic resonance imaging, progression in the severity of ACS, a history of contralateral transient ischemic attack/stroke, microemboli detection on transcranial Doppler, etc.), provided documented perioperative stroke/death rates are <3% and the patient's life expectancy is >5 years. Besides these clinical/imaging characteristics, there are additional individual, ethnic/racial or social factors that should probably be evaluated in the decision process regarding the optimal management of these patients, such as individual patient needs/patient choice, patient compliance with best medical treatment, patient sex, culture, race/ethnicity, age and comorbidities, as well as improvements in imaging/operative techniques/outcomes. The present multispecialty position paper will present the rationale why the management of patients with ACS may need to be individualized.

Indexed as

Carotid stenosisEndarterectomy, carotidIschemic attack, transientLife expectancyPatient preferenceStroke

Identifiers

PMID34102755
PMCPMC8189852
OpenAlexW3172269449

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.