Evidence map›Paper›PMID 34102706›Full record

ArticleChemistryOpen2021

Identification of anti-Parkinson's Disease Lead Compounds from Aspergillus ochraceus Targeting Adenosin Receptors A

Linzhen Hu, Shuying Tian, Rongrong Wu, Zhou Tong, Wen Jiang, Ping Hu, Xueyang Xiao, Xueke Zhang, Hui Zhou, Qingyi Tong and 4 more

Abstract read
In one paragraph

Article in ChemistryOpen, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Molecules (Basel, Switzerland) · 2022
    Review
  4. Article
  5. Review
  6. New Metabolites fromMolecules (Basel, Switzerland) · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Linzhen HuHubei Collaborative Innovation Centre for Green Transformation of Bio-Resources, School of Life Sciences, Hubei University, 430062, Wuhan, China.ORCID 0000-0002-9090-3179
Shuying TianHubei Collaborative Innovation Centre for Green Transformation of Bio-Resources, School of Life Sciences, Hubei University, 430062, Wuhan, China.
Rongrong WuHubei Collaborative Innovation Centre for Green Transformation of Bio-Resources, School of Life Sciences, Hubei University, 430062, Wuhan, China.
Zhou TongHubei Collaborative Innovation Centre for Green Transformation of Bio-Resources, School of Life Sciences, Hubei University, 430062, Wuhan, China.
Wen JiangHubei Collaborative Innovation Centre for Green Transformation of Bio-Resources, School of Life Sciences, Hubei University, 430062, Wuhan, China.
Ping HuHubei Collaborative Innovation Centre for Green Transformation of Bio-Resources, School of Life Sciences, Hubei University, 430062, Wuhan, China.
Xueyang XiaoHubei Collaborative Innovation Centre for Green Transformation of Bio-Resources, School of Life Sciences, Hubei University, 430062, Wuhan, China.
Xueke ZhangHubei Collaborative Innovation Centre for Green Transformation of Bio-Resources, School of Life Sciences, Hubei University, 430062, Wuhan, China.
Hui ZhouHubei Collaborative Innovation Centre for Green Transformation of Bio-Resources, School of Life Sciences, Hubei University, 430062, Wuhan, China.
Qingyi TongSchool of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.
Yuanyuan LuMaternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, 430070, Wuhan, China.
Zhiyong HuangHubei Collaborative Innovation Centre for Green Transformation of Bio-Resources, School of Life Sciences, Hubei University, 430062, Wuhan, China.ORCID 0000-0001-5374-3973
Yong ChenHubei Collaborative Innovation Centre for Green Transformation of Bio-Resources, School of Life Sciences, Hubei University, 430062, Wuhan, China.
Yonghui ZhangSchool of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.ORCID 0000-0002-7222-2142

Funding

Innovation and Entrepreneurship Training Program for Undergraduates S201910512010Innovation and Entrepreneurship Training Program for Undergraduates S202010512054Innovative Training Program for Undergraduates M20191003National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology M20181008National Natural Science Foundation of China 31700294National Natural Science Foundation of China 31700298Pharmaceutical "Jingchu Outstanding Talent" Collaborative Education Program
6 · The paper itself

Abstract

Two novel alkaloids compounds together with fifteen know metabolites were identified from Aspergillus ochraceus. The stereochemistry features of the new molecules were determined via HRESIMS, NMR, ECD, and XRD analyses. Amongst these, compounds two compounds exhibited potential efficacy as anti-Parkinson's disease with the EC

Indexed as

Adenosine A2 Receptor AntagonistsAnimalsAntiparkinson AgentsAspergillus ochraceusCell Line, TumorDrug Evaluation, PreclinicalFemaleHumansMaleMiceMolecular Docking SimulationMolecular Dynamics SimulationNeuroprotective AgentsRatsReceptor, Adenosine A2AStereoisomerismAdenosine A2 Receptor AntagonistsAntiparkinson AgentsNeuroprotective AgentsReceptor, Adenosine A2Aadenosine receptorsalkaloidsAspergillus ochraceusdrug discoveryParkinson's diseasevirtual screening

Identifiers

PMID34102706
PMCPMC8186885

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.