Evidence map›Paper›PMID 34102506›Full record

ArticleDrug and alcohol dependence2021

Trends in homelessness and injection practices among young urban and suburban people who inject drugs: 1997-2017.

Anna Hotton, Mary-Ellen Mackesy-Amiti, Basmattee Boodram

Open access · greenAbstract read
In one paragraph

Article in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  14. Using illicit drugs alone in Vancouver, Canada: a gender-based analysis.Substance abuse treatment, prevention, and policy · 2025
    Article
  15. Review
  16. Article
  17. Sleep Health among Community-Recruited Opioid-Using People Who Inject Drugs in Los Angeles, CA and Denver, CO.Journal of urban health : bulletin of the New York Academy of Medicine · 2024
    Article
  18. Observational
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Anna HottonDepartment of Medicine, University of Chicago, Chicago, IL, United States. Electronic address: ahotton@medicine.bsd.uchicago.edu.
Mary-Ellen Mackesy-AmitiCommunity Outreach Intervention Projects, School of Public Health, University of Illinois at Chicago, Chicago, IL, United States.
Basmattee BoodramCommunity Outreach Intervention Projects, School of Public Health, University of Illinois at Chicago, Chicago, IL, United States; Division of Community Health Sciences, School of Public Health, University of Illinois at Chicago, Chicago, IL, United States.
Chicago Department of Public Health · USUniversity of Chicago · USUniversity of Illinois Chicago · US

Funding

Computational modeling for HCV vaccine trial design and optimal vaccine-based combination interventionsR01AI158666 · NIAID · LOYOLA UNIVERSITY CHICAGO · PI Basmattee Boodram, Harel Dahari · 2022 to 2026
$3.5M
Contextual risk factors for hepatitis C among young persons who inject drugsR01DA043484 · NIDA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BOODRAM, BASMATTEE · 2017 to 2021
$2.9M
Computational discovery of effective hepatitis C intervention strategiesR01GM121600 · NIGMS · LOYOLA UNIVERSITY CHICAGO · PI BOODRAM, BASMATTEE, DAHARI, HAREL · 2017 to 2021
$2.0M
NIAID NIH HHS R01 AI158666NIDA NIH HHS R01 DA043484NIGMS NIH HHS R01 GM121600
6 · The paper itself

Abstract

backgroundAmong young people who inject drugs (PWID) homelessness is associated with numerous adverse psychosocial and health consequences, including risk of relapse and overdose, psychological distress and suicidality, limited treatment access, and injection practices that increase the risk of HIV and hepatitis C (HCV) transmission. Homeless PWID may also be less likely to access sterile syringes through pharmacies or syringe service programs.

methodsThis study applied random-effects meta-regression to examine trends over time in injection risk behaviors and homelessness among young PWID in Chicago and surrounding suburban and rural areas using data from 11 studies collected between 1997 and 2017. In addition, subject-level data were pooled to evaluate the effect of homelessness on risk behaviors across all studies using mixed effects logistic and negative binomial regression with random study effects.

resultsThere was a significant increase in homelessness among young PWID over time, consistent with the general population trend of increasing youth homelessness. In mixed-effects regression, homelessness was associated with injection risk behaviors (receptive syringe sharing, syringe mediated sharing, equipment sharing) and exchange sex, though we detected no overall changes in risk behavior over time.

conclusionsIncreases over time in homelessness among young PWID highlight a need for research to understand factors contributing to youth homelessness to inform HIV/STI, HCV, and overdose prevention and intervention services for this population.

Indexed as

HIV InfectionsIll-Housed PersonsPharmaceutical PreparationsSexually Transmitted DiseasesSubstance Abuse, IntravenousAdolescentHumansNeedle-Exchange ProgramsNeedle SharingRisk-TakingPharmaceutical Preparationshomelessnessinjection risk behaviormeta-regressionpeople who inject drugstime trends

Identifiers

PMID34102506
PMCPMC9373853
OpenAlexW3170906712

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.