ArticleImmunity2021
Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8
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Article in Immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 523 papers, 1 of them a synthesis that pooled it.
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523citing papers in PubMed, 1 pooled it
35.8field-weighted citation impact, top 1% of its field
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Who cites it
523 citing papers in PubMed, 1 synthesis or guideline pooled it, 699 citations in OpenAlex.
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463 more citing papers are in PubMed but not listed here.
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Authors and funding
28 authors at 10 institutions in 3 countries.
Shihao XuNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Omkar ChaudharySection of Infectious Diseases, Yale School of Medicine, New Haven, CT 06510, USA.
Patricia Rodríguez-MoralesNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Xiaoli SunDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Dan ChenNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Roberta ZappasodiLudwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Ziyan XuNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
Antonio F M PintoMass Spectrometry Core for Proteomics and Metabolomics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
April WilliamsThe Razavi Newman Integrative Genomics and Bioinformatics Core Facility, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Isabell SchulzeLudwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Yagmur FarsakogluNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Siva Karthik VaranasiNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Jun Siong LowDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA; Fondazione per l'istituto di ricerca in biomedicina, Bellinzona, Switzerland.
Wenxi TangDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Haiping WangDepartment of Fundamental Oncology, Ludwig Institute for Cancer Research at University of Lausanne, Lausanne, Switzerland.
Bryan McDonaldNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Victoria TrippleNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Michael DownesGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Ronald M EvansGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Nada A AbumradDivision of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Taha MerghoubLudwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Jedd D WolchokLudwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Maxim N ShokhirevThe Razavi Newman Integrative Genomics and Bioinformatics Core Facility, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Ping-Chih HoDepartment of Fundamental Oncology, Ludwig Institute for Cancer Research at University of Lausanne, Lausanne, Switzerland.
Joseph L WitztumDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Brinda EmuSection of Infectious Diseases, Yale School of Medicine, New Haven, CT 06510, USA.
Guoliang CuiT Cell Metabolism Group (D140), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120 Heidelberg, Germany. Electronic address: g.cui@dkfz-heidelberg.de.
Susan M KaechNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: skaech@salk.edu.
Salk Institute for Biological Studies · USUniversity of California, San Diego · USYale University · USParker Institute for Cancer Immunotherapy · USCornell University · USHeidelberg University · DELudwig Cancer Research · CHUniversity of Lausanne · CHWashington University in St. Louis · USWeill Cornell Medicine · US
Funding
VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9MTumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Jackson · 1985 to 2026
$107.2MViral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Ye Zheng · 1985 to 2026
$82.8MYeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2MHORMONAL REGULATION OF MAMMALIAN GENE EXPRESSIONR37DK057978 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2000 to 2019
$16.0MThe Discovery of Human Peptide Encoding GenesR01GM102491 · NIGMS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI O'SHEA, CLODAGH, SAGHATELIAN, ALAN · 2012 to 2025
$5.5MHigh-throughput mapping of selectively vulnerable cell types and projections in aging and Alzheimer's DiseaseRF1AG064049 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI LEE, KUO-FEN, ZADOR, ANTHONY M · 2019 to 2019
$4.7MSpatial Regulation of Developmental Gene ExpressionR01HL105278 · NHLBI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2011 to 2019
$4.0MEngineering human islet-like organoids for transplantationR01DK120480 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2018 to 2021
$3.4M(PQ1) Lipid Metabolism, Inflammation, and T cell Dysfunction in HIV-associated CancerR01CA206483 · NCI · YALE UNIVERSITY · PI EMU, BRINDA, KAECH, SUSAN M · 2017 to 2021
$3.2MUnderstanding how metabolic heterogeneity in cancer affects the tumor microenvironment and anti-tumor immunityR01CA240909 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI KAECH, SUSAN M · 2020 to 2024
$3.0MNCI NIH HHS P30 CA014195NCI NIH HHS P30 CA023100NCI NIH HHS P30 CA030199NCI NIH HHS R01 CA206483NCI NIH HHS R01 CA240909NHLBI NIH HHS K99 HL148504NHLBI NIH HHS R00 HL148504NHLBI NIH HHS R01 HL105278NHLBI NIH HHS R01 HL148188NIA NIH HHS RF1 AG064049NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK057978NIDDK NIH HHS R01 DK120480NIDDK NIH HHS R37 DK057978NIEHS NIH HHS P42 ES010337NIGMS NIH HHS R01 GM102491NIH HHS S10 OD021815
Abstract
A common metabolic alteration in the tumor microenvironment (TME) is lipid accumulation, a feature associated with immune dysfunction. Here, we examined how CD8
Indexed as
AnimalsBiological TransportCD36 AntigensCD8-Positive T-LymphocytesCell Line, TumorHEK293 CellsHumansLeukocytes, MononuclearLipid PeroxidationLipoproteins, LDLLymphocytes, Tumor-InfiltratingMiceMice, Inbred C57BLMice, TransgenicNeoplasmsReceptors, ScavengerCD36 AntigensLipoproteins, LDLoxidized low density lipoproteinReceptors, ScavengerCD36CD8(+) T cellslipid peroxidationoxidized lipidstumor microenvironment
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