Evidence map›Paper›PMID 34102066›Full record

ReviewAnnual review of vision science2021

Retina Metabolism and Metabolism in the Pigmented Epithelium: A Busy Intersection.

James B Hurley

Abstract readReview
In one paragraph

Review in Annual review of vision science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. [Proliferative diabetic retinopathy: fewer complications with early surgery].Revista medica del Instituto Mexicano del Seguro Social · 2026
    Pooled it
  2. Article
  3. Article
  4. Retbindin Dynamically Redistributes to Preserve Retinal Flavin-Dependent Homeostasis in Response to Riboflavin Availability and Circadian Demand.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Kv2.1/Kv8.2 Channels Regulate Fluid Homeostasis in the Outer Retina.bioRxiv : the preprint server for biology · 2026
    Article
  12. The role of lactate in retinal health and disease: mechanisms and potential therapeutic strategies. A narrative review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Molecular stress and neurovascular injury in the diabetic retina.The Journal of clinical investigation · 2026
    Review

73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

James B HurleyDepartments of Biochemistry and Ophthalmology, University of Washington, Seattle, Washington 98115, USA; email: jbhhh@uw.edu.

Funding

ROD AND CONE RESPONSE CHARACTERISTICSR01EY006641 · NEI · UNIVERSITY OF WASHINGTON · PI JAMES Bryant HURLEY · 1986 to 2026
$10.2M
Control of Photoreceptor MetabolismR01EY017863 · NEI · UNIVERSITY OF WASHINGTON · PI JAMES Bryant HURLEY · 2007 to 2026
$6.4M
Photoreceptor Mitochondria and Ca2+ DynamicsR01EY026020 · NEI · UNIVERSITY OF WASHINGTON · PI BROCKERHOFF, SUSAN E, HURLEY, JAMES BRYANT · 2016 to 2024
$3.6M
Respiration in vivo in the Retina and RPER21EY032597 · NEI · UNIVERSITY OF WASHINGTON · PI HURLEY, JAMES BRYANT · 2021 to 2022
$479k
BINDING OF EXPRESSED ARRESTIN TO RHODOPSINF32EY006641 · NEI · UNIVERSITY OF FLORIDA · PI POPP, MICHAEL P · 1995 to 1997
–
NEI NIH HHS F32 EY006641NEI NIH HHS R01 EY006641NEI NIH HHS R01 EY017863NEI NIH HHS R01 EY026020NEI NIH HHS R21 EY032597
6 · The paper itself

Abstract

The outer retina is nourished from the choroid, a capillary bed just inside the sclera. O

Indexed as

RetinaChoroidEnergy MetabolismRetinal Pigment Epitheliummetabolismphotoreceptorsretinaretinal pigment epithelium

Identifiers

PMID34102066
PMCPMC8922051

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.