Evidence map›Paper›PMID 34101982›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2021

Characterization of ABH-subtype donor-specific antibodies in ABO-A-incompatible kidney transplantation.

Andrew Bentall, Mylvaganam Jeyakanthan, Manjit Braitch, Christopher W Cairo, Todd L Lowary, Stephanie Maier, Anne Halpin, Bruce Motyka, Lu Zou, Lori J West and 1 more

Open access · hybridAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
  4. Antibody-mediated rejection in ABO-incompatible kidney transplantation.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
    Article
  5. Research progress on blood therapy for anti-aging.Journal of advanced research · 2026
    Review
  6. Repeat ABO-B-incompatible living-donor kidney transplantation.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
    Article
  7. ABO-incompatible kidney transplantation: impact of apheresis on graft and patient survival in recipients with low isoagglutinin titer.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Serum antibody screening using glycan arrays.Chemical Society reviews · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Characterization of ABH-subtype donor-specific antibodies in ABO-A-incompatible kidney transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Andrew BentallDepartment of Nephrology, University Hospital, Birmingham, UK.ORCID 0000-0002-8495-9782
Mylvaganam JeyakanthanDepartment of Cardiothoracic Surgery, James Cook University Hospital, Middlesbrough, UK.
Manjit BraitchDepartment of Nephrology, University Hospital, Birmingham, UK.
Christopher W CairoAlberta Glycomics Centre and Department of Chemistry, University of Alberta, Edmonton, AB, Canada.
Todd L LowaryAlberta Glycomics Centre and Department of Chemistry, University of Alberta, Edmonton, AB, Canada.
Stephanie MaierAlberta Transplant Institute and Canadian Donation and Transplantation Research Program, University of Alberta, Edmonton, AB, Canada.
Anne HalpinDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0001-7475-9245
Bruce MotykaDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Lu ZouAlberta Glycomics Centre and Department of Chemistry, University of Alberta, Edmonton, AB, Canada.
Lori J WestDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0002-1990-3651
Simon BallDepartment of Nephrology, University Hospital, Birmingham, UK.
University of Alberta · CANIHR Surgical Reconstruction and Microbiology Research Centre · GBMayo Clinic · US

Funding

CIHR
6 · The paper itself

Abstract

ABO-incompatible (ABOi) transplantation requires preemptive antibody reduction; however, the relationship between antibody-mediated rejection (AMR) and ABO-antibodies, quantified by hemagglutination (HA), is inconsistent, possibly reflecting variable graft resistance to AMR or HA assay limitations. Using an ABH-glycan microarray, we quantified ABO-A antigen-subtype (A-subtype)-specific IgM and IgG in 53 ABO-O recipients of ABO-A kidneys, before and after antibody removal (therapeutic plasma exchange [TPE] or ABO-A-trisaccharide immunoadsorption [IA]) and 1-year posttransplant. IgM binding to all A-subtypes correlated highly (R

Indexed as

Kidney TransplantationABO Blood-Group SystemAdultBlood Group IncompatibilityGraft RejectionHumansLiving DonorsABO Blood-Group SystemABO incompatibilityantibody biologyantigen biologyclinical research/practiceglycomicshistocompatibilitykidney transplantation/nephrologytranslational research/science

Identifiers

PMID34101982
PMCPMC8597088
OpenAlexW3170734856

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.