SynthesisThe journal of prevention of Alzheimer's disease
Association of Subjective Cognitive Decline with Risk of Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of Prospective Longitudinal Studies.
Synthesis in The journal of prevention of Alzheimer's disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- SCD-plus features and AD biomarkers in cognitively unimpaired samples: A meta-analytic approach for nine cohort studies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Subjective cognitive decline and objective cognitive performance in older adults: A systematic review of longitudinal and cross-sectional studies.Journal of neuropsychology · 2025Pooled it
- Targeting brain health in subjective cognitive decline: insights from a multidomain randomized controlled trial.Aging clinical and experimental research · 2025Trial
- Citrus supplementation in subjective cognitive decline: results of a 36-week, randomized, placebo-controlled trial.Nutrition journal · 2024Trial
- Observational
- Age and sex differences in cognitive performance in people with subjective cognitive decline and associated worry: Findings from the Canadian Longitudinal Study on Aging.Journal of neuropsychology · 2026Article
- Frailty Components as Moderators of the Subjective Cognitive Decline-Depressive Symptoms Association: A Sex-Stratified Population-Based Study.Healthcare (Basel, Switzerland) · 2026Article
- Diagnostic Performance and Clinical Utility of Automated Plasma Amyloid-β 1-42/1-40 Assay.Diagnostics (Basel, Switzerland) · 2026Article
- The impact of lactate and lipid metabolism in microglia upon cognitive impairment following radiation-induced brain injury.Journal of translational medicine · 2026Review
- Association of plasma biomarkers with amyloid and tau PET in pre-dementia stages.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Heterogeneity in healthy aging among U.S. Latinos: a dual functionality perspective.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Subjective Memory Impairment in the General Adult Population: Associations With Early-Life Cognition, Concurrent Objective Memory, Dementia Risk Factors.European journal of neurology · 2026Article
- The association between handgrip strength, physical, and cognitive function among hospitalized older adults in Tanzania.BMC geriatrics · 2026Article
- Article
- Diagnostic performance of verbal fluency measures: a cross-sectional study in the stages of cognitive continuum.Alzheimer's research & therapy · 2026Article
- The effect of subjective perception of memory and objective cognitive performance on negative affective symptoms in older adults.BMC geriatrics · 2026Article
- Loneliness and cognitive decline among U.S. adults: A stratified analysis of the BRFSS.PloS one · 2026Article
- Demographic and clinical influences on emotion prosody recognition.Frontiers in psychology · 2026Article
- Feasibility and acceptability of two remote physical activity programs for older Latino adults: the C.E.R.E.B.R.O. study, a pilot randomized trial.Frontiers in medicine · 2026Article
- Clinical definition, biological characterization, and detection guidelines of subjective cognitive decline due to Alzheimer's disease and related dementia: A position paper from ISTAART SCD PIA.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSubjective cognitive decline (SCD) as an early pathological manifestation of brain aging has become more prevalent among older adults.
objectivesWe aimed to investigate the associations of subjective cognitive decline (SCD) with the combined risk of cognitive impairment and dementia.
designWe performed a systematic review and meta-analysis via searching Embase, PubMed and Cochrane electronic databases from January 1 st 1970 to June 4th, 2020.
settingProspective cohort studies Participants: Healthy individuals were recruited from community, clinics and population. MEASUREMENTS: Healthy individuals with SCD were classified into exposure groups, while those without were considered as the reference group. Adjusted relative risks (RR) were estimated in a random-effects model. Both primary and subgroup analyses were conducted.
resultsOf 28,895 identified studies, 21 studies containing 22 cohorts were eligible for inclusion in the meta-analysis. SCD increased the risk of subsequent cognitive disorders (RR=2.12, 95% confidence intervals [CI] =1.75-2.58, I2=87%, P<0.01). To be specific, SCD conferred a 2.29-fold excess risk for cognitive impairment (RR=2.29, 95% CI=1.66-3.17, I2=83%, P<0.01) and a 2.16-fold excess risk for dementia (RR=2.16, 95% CI=1.63-2.86, I2=81%, P<0.01). In subgroup analyses, participants with SCD in the subgroup of 65-75 years old, long-education (>15 years) subgroup and subgroup of clinics showed a higher risk of developing objective cognitive disorders.
conclusionsSCD is associated with an increased combined risk of cognitive impairment and incident dementia and should be considered a risk factor for objective cognitive disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.