Observational studyPloS one2021
Associations between low body mass index and mortality in patients with sepsis: A retrospective analysis of a cohort study in Japan.
Observational study in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Impact of underweight status on mortality in sepsis patients: a meta-analysis.Frontiers in medicine · 2025Pooled it
- Evaluating the obesity paradox in patients with sepsis and cancer.International journal of obesity (2005) · 2025Article
- One-year outcomes in sepsis: a prospective multicenter cohort study in Japan.Journal of intensive care · 2025Article
- A Multivariate Phenotypical Approach of Sepsis and Septic Shock-A Comprehensive Narrative Literature Review.Medicina (Kaunas, Lithuania) · 2024Review
- The Association of Body Mass Index and Waist Circumference with Sepsis-Related Mortality in South Korea.Diagnostics (Basel, Switzerland) · 2024Article
- Utility of Lean Body Mass Equations and Body Mass Index for Predicting Outcomes in Critically Ill Adults with Sepsis: A Retrospective Study.Diseases (Basel, Switzerland) · 2024Article
- Diabetes-Related Mortality in a Developing Country: An Exploration of Tertiary Hospital Data.Journal of clinical medicine · 2023Article
- Association of obesity and mortality in sepsis patients: A meta-analysis from observational evidence.Heliyon · 2023Article
- Association of body mass index with mortality of sepsis or septic shock: an updated meta-analysis.Journal of intensive care · 2023Article
- Mortality risks associated with empirical antibiotic activity in Escherichia coli bacteraemia: an analysis of electronic health records.The Journal of antimicrobial chemotherapy · 2022Article
- Prognostic factors in mobility disability among elderly patients in the emergency department: A single-center retrospective study.Acute medicine & surgeryArticle
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Authors and funding
13 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe distribution of body mass in populations of Western countries differs from that of populations of East Asian countries. In East Asian countries, fewer people have a high body mass index than those in Western countries. In Japan, the country with the highest number of older adults worldwide, many people have a low body mass index. Therefore, this study aimed to determine the association between a low body mass index and mortality in patients with sepsis in Japan.
methodsWe conducted this retrospective analysis of 548 patients with severe sepsis from a multicenter prospective observational study. Multivariate logistic regression analyses determined the association between body mass index and 28-day mortality adjusted for age, sex, pre-existing conditions, the occurrence of septic shock, Acute Physiology and Chronic Health Evaluation II scores, and Sequential Organ Failure Assessment scores. Furthermore, the association between a low body mass index and 28-day mortality was analyzed.
resultsThe low body mass index group represented 18.8% of the study population (103/548); the normal body mass index group, 57.3% (314/548); and the high body mass index group, 23.9% (131/548), with the 28-day mortality rates being 21.4% (22/103), 11.2% (35/314), and 14.5% (19/131), respectively. In the low body mass index group, the crude and adjusted odds ratios (95% confidence intervals) for 28-day mortality relative to the non-low body mass index (normal and high body mass index groups combined) group were 2.0 (1.1-3.4) and 2.3 (1.2-4.2), respectively.
conclusionA low body mass index was found to be associated with a higher 28-day mortality than the non-low body mass index in patients with sepsis in Japan. Given that older adults often have a low body mass index, these patients should be monitored closely to reduce the occurrence of negative outcomes.
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