Evidence map›Paper›PMID 34101533›Full record

ArticleAutophagy2022

Enhanced autophagy in

Chenran Wang, Michael Haas, Syn Kok Yeo, Salwa Sebti, Álvaro F Fernández, Zhongju Zou, Beth Levine, Jun-Lin Guan

Open access · bronzeAbstract read
In one paragraph

Article in Autophagy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 38 citations in OpenAlex.

  1. The Hallmarks of Aging: From Molecular Mechanisms to Clinical Translation.International journal of molecular sciences · 2026
    Review
  2. Autophagy activation by the Becn1Brain, behavior, and immunity · 2026
    Article
  3. Article
  4. Review
  5. Autophagy: The convergence point of aging and cancer.Biochemistry and biophysics reports · 2025
    Review
  6. Heavy metal-induced disruption of the autophagy-lysosomal pathway: implications for aging and neurodegenerative disorders.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. The Protective Effects ofInternational journal of molecular sciences · 2023
    Article
  18. Article
  19. BECN1Autophagy · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chenran WangDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Michael HaasDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Syn Kok YeoDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Salwa SebtiCenter for Autophagy Research, Department of Internal Medicine, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Álvaro F FernándezCenter for Autophagy Research, Department of Internal Medicine, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Zhongju ZouCenter for Autophagy Research, Department of Internal Medicine, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-3937-5902
Beth LevineCenter for Autophagy Research, Department of Internal Medicine, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-1460-1638
Jun-Lin GuanDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Howard Hughes Medical Institute · USUniversity of Cincinnati Medical Center · US

Funding

Mechanisms of progression of vascular malformation to lymphangiosarcomaR01HL073394 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUAN, JUN-LIN · 2003 to 2025
$8.4M
Regulation of Neural Stem Cells and Neurogenesis by Autophagy GenesR01NS094144 · NINDS · UNIVERSITY OF CINCINNATI · PI GUAN, JUN-LIN · 2015 to 2024
$3.6M
Mechanisms of FIP200 regulation of breast cancer through its autophagy and non-autophagy functionsR01CA211066 · NCI · UNIVERSITY OF CINCINNATI · PI JUN-LIN GUAN · 2017 to 2026
$3.4M
Regulation of Lipid Catabolism by Autophagy in Neural Stem Cell of Tuberous Sclerosis ComplexR01NS103981 · NINDS · UNIVERSITY OF CINCINNATI · PI WANG, CHENRAN · 2018 to 2022
$1.8M
NCI NIH HHS R01 CA211066NHLBI NIH HHS R01 HL073394NINDS NIH HHS R01 NS094144NINDS NIH HHS R01 NS103981
6 · The paper itself

Abstract

Macroautophagy/autophagy is emerging as a major pathway that regulates both aging and stem cell function. Previous studies have demonstrated a positive correlation of autophagy with longevity; however, these studies did not directly address the consequence of altered autophagy in stem cells during aging. In this study, we used

Indexed as

AutophagyNeural Stem CellsAgingAnimalsBeclin-1MiceNeurogenesisBeclin-1Becn1 protein, mouseAgingbeclin 1 mutant mouseincreased autophagyneural stem cellsneurogenesisself-renewal

Identifiers

PMID34101533
PMCPMC8942493
OpenAlexW3171242493

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.