Evidence map›Paper›PMID 34101429›Full record

ArticleACS infectious diseases2021

Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439.

David M Shackleford, Francis C K Chiu, Kasiram Katneni, Scott Blundell, Jenna McLaren, Xiaofang Wang, Lin Zhou, Kamaraj Sriraghavan, André M Alker, Daniel Hunziker and 9 more

Open access · hybridAbstract read
In one paragraph

Article in ACS infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Synthesis and antimalarial activity of amide and ester conjugates of siderophores and ozonides.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 3 countries.

David M ShacklefordCentre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.
Francis C K ChiuCentre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.
Kasiram KatneniCentre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.
Scott BlundellCentre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.
Jenna McLarenCentre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.
Xiaofang WangCollege of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Lin ZhouCollege of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Kamaraj SriraghavanCollege of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, Nebraska 68198, United States.
André M AlkerRoche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH-4070 Basel, Switzerland.
Daniel HunzikerRoche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH-4070 Basel, Switzerland.
Christian ScheurerSwiss Tropical and Public Health Institute, Socinstrasse 57, CH-4002 Basel, Switzerland.
Qingjie ZhaoCollege of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Yuxiang DongCollege of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, Nebraska 68198, United States.ORCID 0000-0003-1412-3178
Jörg J MöhrleMedicines for Malaria Venture, 20 Route de Pré-Bois, CH-1215 Geneva 15, Switzerland.
Nada AblaMedicines for Malaria Venture, 20 Route de Pré-Bois, CH-1215 Geneva 15, Switzerland.
Hugues MatileRoche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH-4070 Basel, Switzerland.
Sergio WittlinSwiss Tropical and Public Health Institute, Socinstrasse 57, CH-4002 Basel, Switzerland.
Jonathan L VennerstromCollege of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, Nebraska 68198, United States.ORCID 0000-0003-0075-2336
Susan A CharmanCentre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.ORCID 0000-0003-1753-8213
Monash University · AUNebraska Medical Center · USRoche (Switzerland) · CHMedicines for Malaria Venture · CHSwiss Tropical and Public Health Institute · CH

Funding

Optimization of Antischistosomal ChemotypesR01AI116723 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI VENNERSTROM, JONATHAN L · 2015 to 2024
$6.2M
NIAID NIH HHS R01 AI116723
6 · The paper itself

Abstract

OZ439 is a potent synthetic ozonide evaluated for the treatment of uncomplicated malaria. The metabolite profile of OZ439 was characterized

Indexed as

AntimalarialsCytochrome P-450 CYP3ACytochrome P-450 Enzyme SystemHumansMicrosomes, LiverPeroxidesAntimalarialsCytochrome P-450 CYP3ACytochrome P-450 Enzyme SystemPeroxidescytochrome P450 inhibitioncytochrome P450 metabolismmalariametabolite identificationOZ439 (artefenomel)time-dependent inhibition

Identifiers

PMID34101429
PMCPMC8802618
OpenAlexW3169607576

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.