Evidence map›Paper›PMID 34101387›Full record

GuidelineArthritis care & research2021

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.

Liana Fraenkel, Joan M Bathon, Bryant R England, E William St Clair, Thurayya Arayssi, Kristine Carandang, Kevin D Deane, Mark Genovese, Kent Kwas Huston, Gail Kerr and 27 more

Open access · greenAbstract readPractice GuidelineSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Arthritis care & research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 497 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
497citing papers in PubMed, 13 pooled it
149.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

497 citing papers in PubMed, 13 syntheses or guidelines pooled it, 1,221 citations in OpenAlex.

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437 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

37 authors at 20 institutions in 5 countries.

Liana FraenkelBerkshire Medical Center, Pittsfield, Massachusetts, and Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0002-6148-610X
Joan M BathonColumbia University Irving Medical Center, New York Presbyterian Hospital, New York, New York.
Bryant R EnglandUniversity of Nebraska Medical Center and VA Nebraska-Western Iowa Health Care System, Omaha, Nebraska.ORCID 0000-0002-9649-3588
E William St ClairDuke University Medical Center, Durham, North Carolina.
Thurayya ArayssiWeill Cornell Medicine-Qatar, Doha, Qatar.
Kristine CarandangUniversity of California, San Diego.ORCID 0000-0002-0159-6374
Kevin D DeaneUniversity of Colorado, Aurora.ORCID 0000-0003-2211-4861
Mark GenoveseStanford University Medical Center, Palo Alto, California.ORCID 0000-0001-5294-4503
Kent Kwas HustonThe Center for Rheumatic Disease/Allergy and Immunology, Kansas City, Missouri.
Gail KerrVeterans Affairs Medical Center, Georgetown and Howard University, Washington, DC.
Joel KremerAlbany Medical College and The Center for Rheumatology, Albany, New York.ORCID 0000-0001-6674-9901
Mary C NakamuraUniversity of California, San Francisco.
Linda A RussellHospital for Special Surgery, New York, New York.
Jasvinder A SinghUniversity of Alabama at Birmingham and Birmingham Veterans Affairs Medical Center, Birmingham, Alabama.ORCID 0000-0003-3485-0006
Benjamin J SmithFlorida State University College of Medicine School of Physician Assistant Practice, Tallahassee.ORCID 0000-0002-6612-0473
Jeffrey A SparksBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-5556-4618
Shilpa VenkatachalamGlobal Healthy Living Foundation, Upper Nyack, New York.
Michael E WeinblattBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Mounir Al-GibbawiAmerican University of Beirut, Beirut, Lebanon.
Joshua F BakerCorporal Michael J. Crescenz VA Medical Center and the University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0003-0799-7563
Kamil E BarbourCenters for Disease Control and Prevention, Atlanta, Georgia.ORCID 0000-0003-0546-6742
Jennifer L BartonOregon Health & Science University and VA Portland Health Care System, Portland, Oregon.
Laura CappelliJohns Hopkins Medicine, Baltimore, Maryland.ORCID 0000-0003-2795-7059
Fatimah ChamseddineAmerican University of Beirut, Beirut, Lebanon.
Michael GeorgeUniversity of Pennsylvania, Philadelphia.ORCID 0000-0002-0398-2308
Sindhu R JohnsonToronto Western Hospital, Mount Sinai Hospital, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-0591-2976
Lara KahaleAmerican University of Beirut, Beirut, Lebanon.
Basil S KaramAmerican University of Beirut, Beirut, Lebanon.
Assem M KhamisAmerican University of Beirut, Beirut, Lebanon.ORCID 0000-0002-5567-7065
Iris Navarro-MillánWeill Cornell Medicine, New York, New York.ORCID 0000-0002-9540-6614
Reza MirzaUniversity of Toronto, Toronto, Ontario, Canada.
Pascale SchwabOregon Health & Science University and VA Portland Health Care System, Portland, Oregon.
Namrata SinghUniversity of Washington, Seattle.
Marat TurgunbaevAmerican College of Rheumatology, Atlanta, Georgia.
Amy S TurnerAmerican College of Rheumatology, Atlanta, Georgia.ORCID 0000-0001-7695-2022
Sally YaacoubAmerican University of Beirut, Beirut, Lebanon.ORCID 0000-0003-0819-1561
Elie A AklAmerican University of Beirut, Beirut, Lebanon.
American University of Beirut · LBAmerican College of Rheumatology · USBrigham and Women's Hospital · USVA Portland Health Care System · USBerkshire Medical Center · USCenter for Rheumatology · USCenters for Disease Control and Prevention · USCornell University · USDuke Medical Center · USFlorida State University · USGlobal Healthy Living Foundation · USHospital for Special Surgery · USHoward University · USInstitute for Rheumatic Diseases (Japan) · JPJohns Hopkins University · USMount Sinai Hospital · CANewYork–Presbyterian Hospital · USPalo Alto University · USPhiladelphia VA Medical Center · USUniversity of Alabama at Birmingham · US

Funding

Goal concordance in rheumatoid arthritis in diverse populationsK23AR064372 · NIAMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI BARTON, JENNIFER L · 2015 to 2019
$805k
NIAMS NIH HHS K23 AR064372
6 · The paper itself

Abstract

objectiveTo develop updated guidelines for the pharmacologic management of rheumatoid arthritis.

methodsWe developed clinically relevant population, intervention, comparator, and outcomes (PICO) questions. After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the certainty of evidence. A voting panel comprising clinicians and patients achieved consensus on the direction (for or against) and strength (strong or conditional) of recommendations.

resultsThe guideline addresses treatment with disease-modifying antirheumatic drugs (DMARDs), including conventional synthetic DMARDs, biologic DMARDs, and targeted synthetic DMARDs, use of glucocorticoids, and use of DMARDs in certain high-risk populations (i.e., those with liver disease, heart failure, lymphoproliferative disorders, previous serious infections, and nontuberculous mycobacterial lung disease). The guideline includes 44 recommendations (7 strong and 37 conditional).

conclusionThis clinical practice guideline is intended to serve as a tool to support clinician and patient decision-making. Recommendations are not prescriptive, and individual treatment decisions should be made through a shared decision-making process based on patients' values, goals, preferences, and comorbidities.

Indexed as

Antirheumatic AgentsArthritis, RheumatoidClinical Decision-MakingConsensusDecision Support TechniquesHumansRemission InductionRheumatologyTreatment OutcomeAntirheumatic Agents

Identifiers

PMID34101387
PMCPMC9273041
OpenAlexW3171954900

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.