Observational studyJournal of neuroimaging : official journal of the American Society of Neuroimaging2021
Cyclical aspiration using a novel mechanical thrombectomy device is associated with a high TICI 3 first pass effect in large-vessel strokes.
Observational study in Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- The role of first pass effect in mechanical thrombectomy for vertebrobasilar artery occlusion: a comprehensive meta-analysis of prevalence, outcomes, and predictive factors.Journal of neurointerventional surgery · 2026Pooled it
- In-Vitro Comparison of Cyclic Aspiration and Superbore Aspiration Catheters to Conventional 6Fr Aspiration for LVO Stroke.Clinical neuroradiology · 2026Article
- Beyond the Catheter: Contemporary Aspiration Pump Systems in Neurointerventional Stroke Therapy.Stroke (Hoboken, N.J.) · 2026Review
- Triple Aspiration versus Conventional Aspiration Techniques: A Randomized In Vitro Evaluation.AJNR. American journal of neuroradiology · 2025Article
- Cyclic Aspiration in Mechanical Thrombectomy: Influencing Factors and Experimental Validation.AJNR. American journal of neuroradiology · 2024Article
- Predictors and Outcomes of Excellent Recanalization Versus Successful Recanalization After Thrombectomy in Proximal and Distal Medium Vessel Occlusion Strokes: A Multinational Study.Stroke (Hoboken, N.J.) · 2024Article
- The pioneering past and cutting-edge future of interventional neuroradiology.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024Review
- Impact of obesity-related indicators on first-pass effect in patients with ischemic stroke receiving mechanical thrombectomy.Neuroradiology · 2024Article
- VacLok-Augmented Direct Aspiration Thrombectomy : A Novel Method of an Aspiration First-pass Approach for Acute Ischemic Stroke.Clinical neuroradiology · 2024Article
- Robust Collaterals Are Independently Associated With Excellent Recanalization in Patients With Large Vessel Occlusion Causing Acute Ischemic Stroke.Stroke (Hoboken, N.J.) · 2024Article
- A review of mechanical thrombectomy techniques for acute ischemic stroke.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023Review
- REACT Aspiration Catheters: Clinical Experience and Technical Considerations.Neurointervention · 2022Review
- Cyclical aspiration using a novel mechanical thrombectomy device is associated with a high TICI 3 first pass effect in large-vessel strokes.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021Observational
- Evidence-Based Updates to Thrombectomy: Targets, New Techniques, and Devices.Frontiers in neurology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeComplete reperfusion (TICI 3) after the first thrombectomy attempt or first pass effect (FPE) is associated with best clinical outcomes in large-vessel occlusion (LVO) acute ischemic stroke. While endovascular therapy techniques have improved substantially, FPE remains low (24-30%), and new methods to improve reperfusion efficiency are needed.
methodsIn a prospective observational cohort study, 40 consecutive patients underwent cyclical aspiration thrombectomy using CLEAR
resultsAmong 38 patients who met criteria for LVO, median age was 75 (range 31-96). FPE was high (TICI 3: 26/38 [68%], TICI 2c/3: 29/38 [76%]). Among anterior circulation strokes, core lab-adjudicated FPE remained high (TICI 3: 17/29 [59%], TICI 2c/3: 20/29 [69%]), with excellent final successful revascularization results (Final TICI 3: 24/29 [83%], Final TICI 2c/3: 27/29 [93%]). FPE in the CLEAR-1 cohort was significantly higher compared to FPE using existing devices (meta-analysis) from historical controls (TICI 2c/3: 76% vs. 28%, p = 0.0001). High rates of early neurological improvement were observed (delta NIHSS≥4: 35/38 [92.1%]; delta NIHSS≥10: 27/38 [71%]). Similarly, high rates of good functional outcomes (mRS 0-2: 32/38 [84%]) and low mortality (2/38 [5%]) were observed.
conclusionCyclical aspiration using the CLEAR
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Registered trials
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