ArticleThe Journal of physiology2021
Biochemical and structural basis of the passive mechanical properties of whole skeletal muscle.
Article in The Journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Systematic review of skeletal muscle passive mechanics experimental methodology.Journal of biomechanics · 2021Pooled it
- Effect of knee and hip joint positions on passive stiffness of the rectus femoris and vastus lateralis in healthy individuals.Scientific reports · 2026Trial
- Integrated Opto-Biomechatronics For Single Muscle Fibre Structure-Function Assessment: The MyoRobot 3.0.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Elastic scaffolds reinforced stem cell-laden collagen-derived hybrid hydrogels to engineer 3D anisotropic cellular microenvironment.Materials today. Bio · 2026Article
- Elucidation of Architectural and Compositional Factors Associated With Inter-Individual Variability in Passive Shear Modulus of the Human Vastus Lateralis in Young Healthy Males.Scandinavian journal of medicine & science in sports · 2026Article
- Predicting the compression mechanical properties of muscle from microscale indentation mechanics using multiscale mechanical models.Current research in food science · 2026Article
- MyotonPRO Is Not Comparable to Shear Wave Elastography in the Measurement of Rectus Femoris Muscle Stiffness due to Interference of Subcutaneous Adipose Tissue.Scandinavian journal of medicine & science in sports · 2025Article
- Treatment of Ochronotic Osteoarthropathy and the Evaluation of Selected Lower Limb Muscle Properties, Including the Patellar Tendon: A Case Report and Mini Literature Review.Journal of clinical medicine · 2025Article
- Flexoelectricity in Biological Materials and Its Potential Applications in Biomedical Research.Bioengineering (Basel, Switzerland) · 2025Review
- Collagen type VI regulates TGF-β bioavailability in skeletal muscle in mice.The Journal of clinical investigation · 2025Article
- A cross-sectional study on peroneal muscle echogenicity changes and their effects on balance functions in individuals with chronic ankle instability.Scientific reports · 2025Article
- The effect of storing fiber, fiber bundle, and whole muscle in glycerinated solution on their passive elastic modulus.Scientific reports · 2025Article
- Advancements in skeletal muscle tissue engineering: strategies for repair and regeneration of skeletal muscle beyond self-repair.Regenerative biomaterials · 2025Review
- Low-dose orthotopic cancer implantation permits measurement of longitudinal functional changes associated with cachexia.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- The effects of myosteatosis on skeletal muscle function in older adults.Physiological reports · 2024Review
- Rotational 3D shear wave elasticity imaging: Effect of knee flexion on 3D shear wave propagation in in vivo vastus lateralis.Journal of the mechanical behavior of biomedical materials · 2024Article
- Linking myosin heavy chain isoform shift to mechanical properties and fracture modes in skeletal muscle tissue.Biomechanics and modeling in mechanobiology · 2024Article
- Re‑examining the mechanism of eccentric exercise‑induced skeletal muscle damage from the role of the third filament, titin (Review).Biomedical reports · 2024Review
- The effect of fatty infiltration, revision surgery, and sex on lumbar multifidus passive mechanical properties.JOR spine · 2023Article
- Decoding the Gene Regulatory Network of Muscle Stem Cells in Mouse Duchenne Muscular Dystrophy: Revelations from Single-Nuclei RNA Sequencing Analysis.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Passive mechanical properties of whole skeletal muscle are not as well understood as active mechanical properties. Both the structural basis for passive mechanical properties and the properties themselves are challenging to determine because it is not clear which structures within skeletal muscle actually bear passive loads and there are not established standards by which to make mechanical measurements. Evidence suggests that titin bears the majority of the passive load within the single muscle cell. However, at larger scales, such as fascicles and muscles, there is emerging evidence that the extracellular matrix bears the major part of the load. Complicating the ability to quantify and compare across size scales, muscles and species, definitions of muscle passive properties such as stress, strain, modulus and stiffness can be made relative to many reference parameters. These uncertainties make a full understanding of whole muscle passive mechanical properties and modelling these properties very difficult. Future studies defining the specific load bearing structures and their composition and organization are required to fully understand passive mechanics of the whole muscle and develop therapies to treat disorders in which passive muscle properties are altered such as muscular dystrophy, traumatic laceration, and contracture due to upper motor neuron lesion as seen in spinal cord injury, stroke and cerebral palsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.