Evidence map›Paper›PMID 34101088›Full record

Observational studyJournal of neurovirology2021

Mitochondrial DNA haplogroups and domain-specific neurocognitive performance in adults with HIV.

Karen Volpe, David Samuels, Asha Kallianpur, Ronald Ellis, Donald Franklin, Scott Letendre, Robert K Heaton, Todd Hulgan

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of neurovirology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Karen VolpeVanderbilt University Medical Center, Nashville, TN, USA. karen.e.volpe@vumc.org.ORCID 0000-0001-7417-9275
David SamuelsVanderbilt University School of Medicine, Nashville, TN, USA.
Asha KallianpurCleveland Clinic/Lerner Research Institute, Cleveland, OH, USA.
Ronald EllisUniv. of California San Diego, San Diego, CA, USA.
Donald FranklinUniv. of California San Diego, San Diego, CA, USA.
Scott LetendreUniv. of California San Diego, San Diego, CA, USA.
Robert K HeatonUniv. of California San Diego, San Diego, CA, USA.
Todd HulganVanderbilt University Medical Center, Nashville, TN, USA.
University of California San Diego · USVanderbilt University Medical Center · USCleveland Clinic Lerner College of Medicine · USVanderbilt University · US

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello · 2001 to 2026
$50.4M
Age related determinants of HAND: A 12 year follow-up of CHARTER participantsR01MH107345 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HEATON, ROBERT KERNACHAN, LETENDRE, SCOTT L · 2015 to 2021
$7.9M
Iron and Mitochondrial Genomics in Neuro-inflammation and HAND: A CHARTER StudyR01MH095621 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HULGAN, TODD M, KALLIANPUR, ASHA R · 2011 to 2015
$3.1M
Midcareer Investigator Award in Patient-Oriented NeuroAIDS ResearchK24MH097673 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LETENDRE, SCOTT L · 2013 to 2017
$917k
CNS HIV ANTI-RETROVIRAL THERAPY EFFECTS RESEARCH /CHARTER/ -278022005-278022005N01MH022005 · NIMH · UNIVERSITY OF CA -SAN DIEGO · PI GRANT, IGOR · 2003 to 2006
–
NIMH NIH HHS HHSN271201000030CNIMH NIH HHS HHSN271201000036CNIMH NIH HHS K24 MH097673NIMH NIH HHS N01 MH022005NIMH NIH HHS P30 MH062512NIMH NIH HHS R01 MH095621NIMH NIH HHS R01 MH107345
6 · The paper itself

Abstract

Neurocognitive (NC) impairment (NCI) is an important cause of morbidity in persons with HIV (PWH). In the high-energy environment of the central nervous system, mitochondria contribute to neuroinflammation and aging, which may ultimately drive the pathogenesis of neurodegenerative diseases. Mitochondrial DNA (mtDNA) haplogroups are associated with health outcomes in PWH. For example, we previously observed less global NCI in Hispanic ancestry PWH having mtDNA haplogroup B. Another study reported increased NCI among PWH having African subhaplogroup L2a. We therefore analyzed NC domains in relation to these haplogroups in CNS HIV Antiretroviral Therapy Effects Research (CHARTER), a multi-site observational neuro-HIV study. Haplogroups were assigned using mtDNA sequence in 1016 PWH. Outcomes were NCI, defined by domain deficit score and mean T-scores (TS) for seven NC domains. Ancestry-stratified analyses of NC performance included Wilcoxon rank sum, χ

Indexed as

AdultAIDS Dementia ComplexCross-Sectional StudiesDNA, MitochondrialFemaleHaplotypesHIV InfectionsHumansMaleMiddle AgedDNA, MitochondrialAfrican AmericansDNAHispanic AmericansHIVMitochondrialNeurocognitive disorders

Identifiers

PMID34101088
PMCPMC8527871
OpenAlexW3168768106

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.