Evidence map›Paper›PMID 34101085›Full record

ArticleJournal of neurovirology2021

MRI negative myelopathy post mild SARS-CoV-2 infection: vasculopathy or inflammatory myelitis?

Rory M C Abrams, Farinaz Safavi, Stanley Tuhrim, Allison Navis, Jeremy Steinberger, Susan C Shin

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Journal of neurovirology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  6. Atypical and delayed spinal cord MRI features of COVID-19-associated myelopathies: a report of four cases and literature review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Review
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  16. Online News Coverage of COVID-19 Long Haul Symptoms.Journal of community health · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rory M C AbramsDepartment of Neurology, Icahn School of Medicine At Mount Sinai, 1468 Madison Avenue, New York, NY, 10029, USA.
Farinaz SafaviSection of Infections of Nervous System, Division of Neuroimmunology and Neurovirology NINDS, NIH, Bethesda, Maryland, USA.
Stanley TuhrimDepartment of Neurology, Icahn School of Medicine At Mount Sinai, 1468 Madison Avenue, New York, NY, 10029, USA.
Allison NavisDepartment of Neurology, Icahn School of Medicine At Mount Sinai, 1468 Madison Avenue, New York, NY, 10029, USA.
Jeremy SteinbergerDepartment of Neurosurgery Icahn School of Medicine At Mount Sinai, 1468 Madison Avenue, New York, NY, 10029, USA.
Susan C ShinDepartment of Neurology, Icahn School of Medicine At Mount Sinai, 1468 Madison Avenue, New York, NY, 10029, USA. Susan.Shin@mssm.edu.ORCID 0000-0003-2275-1342
Icahn School of Medicine at Mount Sinai · USNational Institutes of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the onset of the COVID-19 pandemic, there have been rare reports of spinal cord pathology diagnosed as inflammatory myelopathy and suspected spinal cord ischemia after SARS-CoV-2 infection. Herein, we report five cases of clinical myelopathy and myeloradiculopathy in the setting of post-COVID-19 disease, which were all radiographically negative. Unlike prior reports which typically characterized hospitalized patients with severe COVID-19 disease and critical illness, these patients typically had asymptomatic or mild-moderate COVID-19 disease and lacked radiologic evidence of structural spinal cord abnormality. This case series highlights that COVID-19 associated myelopathy is not rare, requires a high degree of clinical suspicion as imaging markers may be negative, and raises several possible pathophysiologic mechanisms.

Indexed as

AgedCOVID-19FemaleHumansMagnetic Resonance ImagingMaleMiddle AgedSARS-CoV-2Spinal Cord DiseasesInflammatory myelopathyIschemic myelopathyLong Haul CovidPost Acute Covid-19 SyndromeTransverse myelopathy syndrome

Identifiers

PMID34101085
PMCPMC8186350
OpenAlexW3168127945

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.