Evidence map›Paper›PMID 34101067›Full record

ArticleAnnals of surgical oncology2021

Exposure to Blood Components and Inflammation Contribute to Pancreatic Cancer Progression.

Ryo Saito, Hiromichi Kawaida, Naohiro Hosomura, Hidetake Amemiya, Jun Itakura, Atsushi Yamamoto, Koichi Takiguchi, Suguru Maruyama, Katsutoshi Shoda, Shinji Furuya and 6 more

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In one paragraph

Article in Annals of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Ryo SaitoFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Chuo, Yamanashi, Japan.
Hiromichi KawaidaFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Chuo, Yamanashi, Japan.
Naohiro HosomuraFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Chuo, Yamanashi, Japan.
Hidetake AmemiyaFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Chuo, Yamanashi, Japan.
Jun ItakuraFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Chuo, Yamanashi, Japan.
Atsushi YamamotoFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Chuo, Yamanashi, Japan.
Koichi TakiguchiFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Chuo, Yamanashi, Japan.
Suguru MaruyamaFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Chuo, Yamanashi, Japan.
Katsutoshi ShodaFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Chuo, Yamanashi, Japan.
Shinji FuruyaFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Chuo, Yamanashi, Japan.
Hidenori AkaikeFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Chuo, Yamanashi, Japan.
Yoshihiko KawaguchiFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Chuo, Yamanashi, Japan.
Makoto SudoFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Chuo, Yamanashi, Japan.
Shingo InoueFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Chuo, Yamanashi, Japan.
Hiroshi KonoFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Chuo, Yamanashi, Japan.
Daisuke IchikawaFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Chuo, Yamanashi, Japan. dichikawa@yamanashi.ac.jp.
University of Yamanashi · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPancreatectomy is a highly invasive procedure with extensive intraoperative blood loss (IBL) and high risk of postoperative pancreatic fistula (POPF). We conducted an experimental and retrospective clinical study to determine whether the malignant behaviors of pancreatic cancer cells were enhanced by exposure to blood components in vitro and to evaluate the oncological significance of high IBL and POPF in pancreatic cancer.

methodsThis study included 107 patients undergoing radical pancreatectomy in the University of Yamanashi Hospital between 2011 and 2017, classified into high (n = 29) and low (n = 78) IBL groups. In vitro experiments included functional analyses of Panc-1 pancreatic cancer and normal mesothelial cells exposed to patient blood components, and clinical data were used to assess the contribution of IBL and POPF to patient outcomes.

resultsThe migration (p = 0.007), invasion (p < 0.001), and proliferation (p < 0.01) of Panc-1 cells were enhanced with platelet coculture. The ability of Panc-1 cells to adhere mesothelial cells was enhanced by plasma coincubation, especially in the presence of inflammation (p < 0.001). High IBL was associated with worse overall survival (p = 0.007) and increased locoregional recurrence (p = 0.003) in patients. POPF enhanced the negative prognostic significance of high IBL (p < 0.001 for overall survival, p = 0.001 for locoregional recurrence), indicating the oncological negative effects of high IBL and POPF.

conclusionsBlood components, especially platelets, and inflammation enhance the malignant behaviors of pancreatic cancer cells, potentially contributing to poor prognosis for pancreatic cancer patients.

Indexed as

Pancreatic FistulaPancreatic NeoplasmsHumansInflammationPancreatectomyPostoperative ComplicationsRetrospective StudiesRisk Factors

Identifiers

PMID34101067
OpenAlexW3169989634

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.