Evidence map›Paper›PMID 34101066›Full record

SynthesisAnnals of surgical oncology2021

Preoperative Cardiopulmonary Exercise Test Associated with Postoperative Outcomes in Patients Undergoing Cancer Surgery: A Systematic Review and Meta-Analyses.

Daniel Steffens, Hilmy Ismail, Linda Denehy, Paula R Beckenkamp, Michael Solomon, Cherry Koh, Jenna Bartyn, Neil Pillinger

3 registry-linked trialsOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Annals of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 50 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 3 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06189131 nasuspendednot on this mapstarted 2023, after this paper: background citation

The Use of Ventriject to Assess V02Max in Patients Admitted to Hospital in the Emergency Surgery Setting

TypeinterventionalSponsorThe Leeds Teaching Hospitals NHS TrustRan2023 to 2025Enrolled68ConditionsEmergencies, SurgeryArmsVentriject
NCT07354971 recruitingnot on this mapstarted 2026, after this paper: background citation

The Immuno-FIT Observational Study: A Phase II Window Observational Study Investigating the Effects of Immunotherapy on Cardiopulmonary Fitness, Quality of Life, and Treatment Outcomes in Patients With Advanced Cancer

TypeobservationalSponsorUniversity Hospital Southampton NHS Foundation TrustRan2026 to 2028Enrolled67ConditionsNeoplasms, Immunotherapy, Physical Fitness, Quality of LifeArmsObservational Study - No Study Intervention
NCT07700459 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Randomised-controlled Trial to Assess the Impact of Prehabilitation and a Structured Exercise Programme on Cardiorespiratory Performance in Adults Awaiting Elective Surgery for Congenital Heart Disease: The ACE-CHD Trial.

TypeinterventionalSponsorLiverpool Heart and Chest Hospital NHS Foundation TrustRan2026 to 2029Enrolled32ConditionsCongenital Heart Disease, Cardiac SurgeryArmsExercise prehabilitation
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. The effects of psychological intervention on negative emotions, pain, and sleep in patients with advanced colon cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Trial
  7. Trial
  8. Trial
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Surgery in Older Cancer Patients.Current oncology reports · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Daniel SteffensSurgical Outcomes Research Centre (SOuRCe), Royal Prince Alfred Hospital (RPAH), Sydney, NSW, Australia. daniel.steffens@health.nsw.gov.au.ORCID http://orcid.org/0000-0002-9715-860X
Hilmy IsmailSchool of Health Sciences, The University of Melbourne, Melbourne, Australia.
Linda DenehySchool of Health Sciences, The University of Melbourne, Melbourne, Australia.
Paula R BeckenkampFaculty of Health Sciences, Discipline of Physiotherapy, Musculoskeletal Health, The University of Sydney, Sydney, Australia.
Michael SolomonSurgical Outcomes Research Centre (SOuRCe), Royal Prince Alfred Hospital (RPAH), Sydney, NSW, Australia.
Cherry KohSurgical Outcomes Research Centre (SOuRCe), Royal Prince Alfred Hospital (RPAH), Sydney, NSW, Australia.
Jenna BartynSurgical Outcomes Research Centre (SOuRCe), Royal Prince Alfred Hospital (RPAH), Sydney, NSW, Australia.
Neil PillingerSurgical Outcomes Research Centre (SOuRCe), Royal Prince Alfred Hospital (RPAH), Sydney, NSW, Australia.
The University of Sydney · AUThe University of Melbourne · AURoyal Prince Alfred Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundsThere is mixed evidence on the value of preoperative cardiorespiratory exercise test (CPET) to predict postoperative outcomes in patients undergoing a cancer surgical procedure. The purpose of this review was to investigate the association between preoperative CPET variables and postoperative complications, length of hospital stay, and quality of life in patients undergoing cancer surgery.

methodsA search was conducted on MEDLINE, Embase, AMED, and Web of science from inception to April 2020. Cohort studies investigating the association between preoperative CPET variables, including peak oxygen uptake (peak VO

resultsFifty-two unique studies, including 10,030 patients were included. Overall, most studies were rated as having low risk of bias. Higher preoperative peak VO

conclusionsThis systematic review and meta-analysis demonstrated a significant association between superior preoperative CPET values, especially peak VO

Indexed as

Exercise TestNeoplasmsHumansLength of StayPostoperative ComplicationsPostoperative PeriodQuality of Life

Identifiers

PMID34101066
PMCPMC8186024
OpenAlexW3166375950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.