Evidence map›Paper›PMID 34101054›Full record

ArticleClinical rheumatology2021

Association analysis of juvenile idiopathic arthritis genetic susceptibility factors in Estonian patients.

Tiit Nikopensius, Priit Niibo, Toomas Haller, Triin Jagomägi, Ülle Voog-Oras, Neeme Tõnisson, Andres Metspalu, Mare Saag, Chris Pruunsild

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Tiit Nikopensius *Estonian Genome Center, Institute of Genomics, University of Tartu, Riia 23B, 51010, Tartu, Estonia. tiitn@ut.ee.
Priit Niibo *Institute of Dentistry, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0001-5223-9054
Toomas HallerEstonian Genome Center, Institute of Genomics, University of Tartu, Riia 23B, 51010, Tartu, Estonia.
Triin JagomägiInstitute of Dentistry, University of Tartu, Tartu, Estonia.
Ülle Voog-OrasInstitute of Dentistry, University of Tartu, Tartu, Estonia.
Neeme TõnissonEstonian Genome Center, Institute of Genomics, University of Tartu, Riia 23B, 51010, Tartu, Estonia.
Andres MetspaluEstonian Genome Center, Institute of Genomics, University of Tartu, Riia 23B, 51010, Tartu, Estonia.
Mare SaagInstitute of Dentistry, University of Tartu, Tartu, Estonia.
Chris PruunsildChildren's Clinic, Tartu University Hospital, Tartu, Estonia.
University of Tartu · EETartu University Hospital · EEEstonian Biocentre · EE

Funding

Estonian Science Foundation ETF9255
6 · The paper itself

Abstract

backgroundJuvenile idiopathic arthritis (JIA) is the most common chronic rheumatic condition of childhood. Genetic association studies have revealed several JIA susceptibility loci with the strongest effect size observed in the human leukocyte antigen (HLA) region. Genome-wide association studies have augmented the number of JIA-associated loci, particularly for non-HLA genes. The aim of this study was to identify new associations at non-HLA loci predisposing to the risk of JIA development in Estonian patients.

methodsWe performed genome-wide association analyses in an entire JIA case-control sample (All-JIA) and in a case-control sample for oligoarticular JIA, the most prevalent JIA subtype. The entire cohort was genotyped using the Illumina HumanOmniExpress BeadChip arrays. After imputation, 16,583,468 variants were analyzed in 263 cases and 6956 controls.

resultsWe demonstrated nominal evidence of association for 12 novel non-HLA loci not previously implicated in JIA predisposition. We replicated known JIA associations in CLEC16A and VCTN1 regions in the oligoarticular JIA sample. The strongest associations in the All-JIA analysis were identified at PRKG1 (P = 2,54 × 10

conclusionThis study increases the number of known JIA risk loci and provides additional evidence for the existence of overlapping genetic risk loci between JIA and other autoimmune diseases, particularly rheumatoid arthritis. The reported loci are involved in molecular pathways of immunological relevance and likely represent genomic regions that confer susceptibility to JIA in Estonian patients. Key Points • Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease with heterogeneous presentation and genetic predisposition. • Present genome-wide association study for Estonian JIA patients is first of its kind in Northern and Northeastern Europe. • The results of the present study increase the knowledge about JIA risk loci replicating some previously described associations, so adding weight to their relevance and describing novel loci. • The study provides additional evidence for the existence of overlapping genetic risk loci between JIA and other autoimmune diseases, particularly rheumatoid arthritis.

Indexed as

Arthritis, JuvenileGenetic Predisposition to DiseaseCase-Control StudiesEstoniaGenome-Wide Association StudyHumansPolymorphism, Single NucleotideGenome-wide association studyJuvenile idiopathic arthritisRheumatoid arthritis

Identifiers

PMID34101054
PMCPMC8463396
OpenAlexW3165959825

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