SynthesisGenetics2021
Meta-analysis identifies pleiotropic loci controlling phenotypic trade-offs in sorghum.
Synthesis in Genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Genomic co-localization of variation affecting agronomic and human gut microbiome traits in a meta-analysis of diverse sorghum.G3 (Bethesda, Md.) · 2024Pooled it
- Translating functional molecular knowledge into crop-breeding success.Nature reviews. Genetics · 2026Review
- Toward Breeding by Gene Design: Constructing the Ideotype ofPlants (Basel, Switzerland) · 2026Review
- An updated molecular toolkit for genomics-assisted breeding of waxy sorghum [Sorghum bicolor (L.) Moench].Journal of applied genetics · 2026Article
- SorghumBase: a knowledgebase for sorghum genomics, phenomics, and stakeholder engagement.Genetics · 2026Article
- Genome-wide association studies and modeling of stomatal gas conductance reveal genetic control of water-use efficiency in sorghum.Plant physiology · 2026Article
- Genome-wide association and haplotype analyses reveal genetic architecture of seed dormancy in grain sorghum with implications for preharvest sprouting tolerance.The plant genome · 2026Article
- Gramene 2025: expanded comparative genomics and pathway resources, integrated search, and pan-genome portals for crop research.Nucleic acids research · 2026Article
- Genes and pathways determining flowering time variation in temperate-adapted sorghum.The Plant journal : for cell and molecular biology · 2025Article
- Beyond the Standard GWAS-A Guide for Plant Biologists.Plant & cell physiology · 2025Review
- Unveiling shared genetic regulators of plant architectural and biomass yield traits in the Sorghum Association Panel.Journal of experimental botany · 2025Article
- Genetic and Environmental Patterns Underlying Phenotypic Plasticity in Flowering Time and Plant Height in Sorghum.Plant, cell & environment · 2025Article
- Epistasis and pleiotropy-induced variation for plant breeding.Plant biotechnology journal · 2024Review
- Multi-trait association mapping for phosphorous efficiency reveals flexible root architectures in sorghum.BMC plant biology · 2024Article
- Deleterious mutations predicted in the sorghum (Sorghum bicolor) Maturity (Ma) and Dwarf (Dw) genes from whole-genome resequencing.Scientific reports · 2023Article
- Elucidating the patterns of pleiotropy and its biological relevance in maize.PLoS genetics · 2023Article
- Gene-by-environment interactions in plants: Molecular mechanisms, environmental drivers, and adaptive plasticity.The Plant cell · 2023Review
- Functional genomic effects of indels using Bayesian genome-phenome wide association studies in sorghum.Frontiers in genetics · 2023Article
- Association mapping across a multitude of traits collected in diverse environments in maize.GigaScience · 2022Article
- Sorghum Association Panel whole-genome sequencing establishes cornerstone resource for dissecting genomic diversity.The Plant journal : for cell and molecular biology · 2022Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Community association populations are composed of phenotypically and genetically diverse accessions. Once these populations are genotyped, the resulting marker data can be reused by different groups investigating the genetic basis of different traits. Because the same genotypes are observed and scored for a wide range of traits in different environments, these populations represent a unique resource to investigate pleiotropy. Here, we assembled a set of 234 separate trait datasets for the Sorghum Association Panel, a group of 406 sorghum genotypes widely employed by the sorghum genetics community. Comparison of genome-wide association studies (GWAS) conducted with two independently generated marker sets for this population demonstrate that existing genetic marker sets do not saturate the genome and likely capture only 35-43% of potentially detectable loci controlling variation for traits scored in this population. While limited evidence for pleiotropy was apparent in cross-GWAS comparisons, a multivariate adaptive shrinkage approach recovered both known pleiotropic effects of existing loci and new pleiotropic effects, particularly significant impacts of known dwarfing genes on root architecture. In addition, we identified new loci with pleiotropic effects consistent with known trade-offs in sorghum development. These results demonstrate the potential for mining existing trait datasets from widely used community association populations to enable new discoveries from existing trait datasets as new, denser genetic marker datasets are generated for existing community association populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.