ArticleGenome biology and evolution2021
Origin and Evolution of the Cannabinoid Oxidocyclase Gene Family.
Article in Genome biology and evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Nutritive Value and Cannabinoid Potency of Diverse Hemp (Journal of agricultural and food chemistry · 2026Article
- The Structure of the Chemotype Determining Locus inPlant direct · 2026Article
- Genome-wide inventory and functional characterization of cannabinoid oxidocyclases inHorticulture research · 2026Article
- Resurrected Ancestral Cannabis Enzymes Unveil the Origin and Functional Evolution of Cannabinoid Synthases.Plant biotechnology journal · 2026Article
- Insights into glandular trichome biology from analysis of organ-specific gene expression programmes in cannabis, hop and tomato.The Plant journal : for cell and molecular biology · 2026Article
- Forensic Identification of Cannabis with Plant DNA Barcodes and Cannabinoid Synthesis Genes.Genes · 2025Article
- Genetic diversity, population structure, and cannabinoid variation in feral Cannabis sativa germplasm from the United States.Scientific reports · 2025Article
- Article
- Discovery of major QTL and a massive haplotype associated with cannabinoid biosynthesis in drug-type Cannabis.The plant genome · 2025Article
- Rapid Specific PCR Detection Based onInternational journal of molecular sciences · 2025Article
- From fibers to flowering to metabolites: unlocking hemp (Cannabis sativa) potential with the guidance of novel discoveries and tools.Journal of experimental botany · 2025Review
- Characterization of the Cannabis sativa glandular trichome epigenome.BMC plant biology · 2024Article
- Genome-wide identification of cannabinoid biosynthesis genes in non-drug type Cannabis (Cannabis sativa L.) cultivar.Journal of cannabis research · 2024Article
- DoesPlants (Basel, Switzerland) · 2024Article
- The evolutionary origin of naturally occurring intermolecular Diels-Alderases from Morus alba.Nature communications · 2024Article
- Cannabinoids function in defense against chewing herbivores inHorticulture research · 2023Article
- An improved assembly of the "Cascade" hop (Horticulture research · 2023Article
- Article
- Profiling Cannabinoid Contents and Expression Levels of Corresponding Biosynthetic Genes in CommercialPlants (Basel, Switzerland) · 2022Article
- High-throughput methods to identify male Cannabis sativa using various genotyping methods.Journal of cannabis research · 2022Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cannabis is an ancient crop representing a rapidly increasing legal market, especially for medicinal purposes. Medicinal and psychoactive effects of Cannabis rely on specific terpenophenolic ligands named cannabinoids. Recent whole-genome sequencing efforts have uncovered variation in multiple genes encoding the final steps in cannabinoid biosynthesis. However, the origin, evolution, and phylogenetic relationships of these cannabinoid oxidocyclase genes remain unclear. To elucidate these aspects, we performed comparative genomic analyses of Cannabis, related genera within the Cannabaceae family, and selected outgroup species. Results show that cannabinoid oxidocyclase genes originated in the Cannabis lineage from within a larger gene expansion in the Cannabaceae family. Localization and divergence of oxidocyclase genes in the Cannabis genome revealed two main syntenic blocks, each comprising tandemly repeated cannabinoid oxidocyclase genes. By comparing these blocks with those in genomes from closely related species, we propose an evolutionary model for the origin, neofunctionalization, duplication, and diversification of cannabinoid oxidocycloase genes. Based on phylogenetic analyses, we propose a comprehensive classification of three main clades and seven subclades that are intended to aid unequivocal referencing and identification of cannabinoid oxidocyclase genes. Our data suggest that cannabinoid phenotype is primarily determined by the presence/absence of single-copy genes. Although wild populations of Cannabis are still unknown, increased sampling of landraces and wild/feral populations across its native geographic range is likely to uncover additional cannabinoid oxidocyclase sequence variants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.