Evidence map›Paper›PMID 34100901›Full record

ArticleBlood advances2021

Blueprint for the discovery of biomarkers of toxicity and efficacy for CAR T cells and T-cell engagers.

Sophie Paczesny, Marcelo C Pasquini, Steven Z Pavletic, Amit Agarwal, Stephen Spellman, Leslie Kean, Chantale Bernatchez, Juliane Gust, Verena Staedtke, Miguel-Angel Perales

Abstract readLetter
In one paragraph

Article in Blood advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sophie PaczesnyDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC.ORCID 0000-0001-5571-2775
Marcelo C PasquiniCenter for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI.ORCID 0000-0003-1579-2293
Steven Z PavleticNational Cancer Institute, National Institutes of Health, Bethesda, MD.
Amit AgarwalBristol Myers Squibb, Summit, NJ.
Stephen SpellmanCenter for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, MN.
Leslie KeanBoston Children's Hospital, Dana-Farber Cancer Institute, Boston, MA.
Chantale BernatchezMD Anderson Cancer Center, Houston, TX.ORCID 0000-0001-5926-3460
Juliane GustSeattle Children's Hospital, Seattle, WA.ORCID 0000-0001-5679-1989
Verena StaedtkeJohns Hopkins Comprehensive Neurofibromatosis Center, Johns Hopkins University, Baltimore, MD; and.
Miguel-Angel PeralesMemorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-5910-4571

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
Novel Biologic Therapies for GVHDR01HL095791 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI KEAN, LESLIE S · 2010 to 2025
$13.3M
NIH Chronic GVHD Study GroupZIABC011743 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PAVLETIC, STEVEN · 2016 to 2025
$10.2M
Immuno-Oncology Translation Network (IOTN): Cellular Immunotherapy Data Resource (CIDR)U24CA233032 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI PASQUINI, MARCELO C. · 2018 to 2019
$9.0M
Adrenergic modulation of cellular immune functions in CAR T cell-induced cytokine release syndromeU01CA247576 · NCI · JOHNS HOPKINS UNIVERSITY · PI BAI, RENYUAN, STAEDTKE, VERENA · 2020 to 2024
$3.1M
The role of catecholamines in immunotoxicity and tumor response of adoptive T cell therapy in cancerK08CA230179 · NCI · JOHNS HOPKINS UNIVERSITY · PI STAEDTKE, VERENA · 2018 to 2022
$1.4M
Blood Brain Barrier Disruption during Chimeric Antigen Receptor (CAR) T cell therapyK08NS118138 · NINDS · SEATTLE CHILDREN'S HOSPITAL · PI GUST, JULIANE · 2020 to 2024
$879k
NCI NIH HHS K08 CA230179NCI NIH HHS U01 CA247576NCI NIH HHS U24 CA076518NCI NIH HHS U24 CA233032NHLBI NIH HHS R01 HL095791NINDS NIH HHS K08 NS118138
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Immunotherapy, AdoptiveT-LymphocytesBiomarkersReceptors, Antigen, T-CellBiomarkersReceptors, Antigen, T-Cell

Identifiers

PMID34100901
PMCPMC8238483

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.