ArticleJournal of medical Internet research2021
Association Between the Digital Clock Drawing Test and Neuropsychological Test Performance: Large Community-Based Prospective Cohort (Framingham Heart Study).
Article in Journal of medical Internet research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Diagnostic accuracy of digital clock drawing test for Alzheimer disease and mild cognitive impairment.NPJ digital medicine · 2026Article
- Streamlining Eligibility Assessment for Alzheimer's Disease-Modifying Therapies: Prediction of MMSE Scores Using the Digital Clock and Recall.medRxiv : the preprint server for health sciences · 2026Article
- Higher Amyloid and Tau Burden Is Associated With Faster Decline on a Digital Cognitive Test.Annals of clinical and translational neurology · 2026Article
- Streamlining eligibility assessment for Alzheimer's disease-modifying therapies: Prediction of MMSE scores using the digital clock and recall.Frontiers in digital health · 2026Article
- Digital clock assessment in South Asian setting: pilot study.NPJ dementia · 2026Article
- Concurrent detection of cognitive impairment and amyloid positivity with a multimodal machine learning-enabled digital cognitive assessment.Alzheimer's research & therapy · 2025Article
- Perioperative Artificial Intelligence Driven Integrated Modeling of Surgeries using Anesthetic, Physical and Cognitive Statuses for Predicting Hospital Outcomes.Research square · 2025Article
- Digital Clock Assessment in South Asian Setting: Pilot study.Research square · 2025Article
- Optimizing mobile cognitive assessment reduces administration time while maintaining screening accuracy in older adults.Scientific reports · 2025Article
- Article
- Association of the digital clock drawing test with amyloid and tau PET biomarkers in low age risk adults.Scientific reports · 2025Article
- Non-equivalence of sub-tasks of the Rey-Osterrieth Complex Figure Test with convolutional neural networks to discriminate mild cognitive impairment.BMC psychiatry · 2024Article
- Digital Clock and Recall: a digital, process-driven evolution of the Mini-Cog.Frontiers in human neuroscience · 2024Article
- Digital clock drawing test reflects visuospatial ability of older drivers.Frontiers in psychology · 2024Article
- Article
- Association Between Acoustic Features and Brain Volumes: the Framingham Heart Study.Frontiers in dementia · 2023Article
- Conventional clock drawing tests have low to moderate reliability and validity for detecting subtle cognitive impairments in community-dwelling older adults.Frontiers in aging neuroscience · 2023Article
- Association Between Acoustic Features and Neuropsychological Test Performance in the Framingham Heart Study: Observational Study.Journal of medical Internet research · 2022Observational
- Associations Between the Digital Clock Drawing Test and Brain Volume: Large Community-Based Prospective Cohort (Framingham Heart Study).Journal of medical Internet research · 2022Article
- Daily Level Association of Physical Activity and Performance on Ecological Momentary Cognitive Tests in Free-living Environments: A Mobile Health Observational Study.JMIR mHealth and uHealth · 2022Observational
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe Clock Drawing Test (CDT) has been widely used in clinic for cognitive assessment. Recently, a digital Clock Drawing Text (dCDT) that is able to capture the entire sequence of clock drawing behaviors was introduced. While a variety of domain-specific features can be derived from the dCDT, it has not yet been evaluated in a large community-based population whether the features derived from the dCDT correlate with cognitive function.
objectiveWe aimed to investigate the association between dCDT features and cognitive performance across multiple domains.
methodsParticipants from the Framingham Heart Study, a large community-based cohort with longitudinal cognitive surveillance, who did not have dementia were included. Participants were administered both the dCDT and a standard protocol of neuropsychological tests that measured a wide range of cognitive functions. A total of 105 features were derived from the dCDT, and their associations with 18 neuropsychological tests were assessed with linear regression models adjusted for age and sex. Associations between a composite score from dCDT features were also assessed for associations with each neuropsychological test and cognitive status (clinically diagnosed mild cognitive impairment compared to normal cognition).
resultsThe study included 2062 participants (age: mean 62, SD 13 years, 51.6% women), among whom 36 were diagnosed with mild cognitive impairment. Each neuropsychological test was associated with an average of 50 dCDT features. The composite scores derived from dCDT features were significantly associated with both neuropsychological tests and mild cognitive impairment.
conclusionsThe dCDT can potentially be used as a tool for cognitive assessment in large community-based populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.