Evidence map›Paper›PMID 34100680›Full record

ArticleRadiology2021

Rapid B

Christina J MacAskill, Michael Markley, Susan Farr, Ashlee Parsons, Jacob R Perino, Kimberly McBennett, Katherine Kutney, Mitchell L Drumm, Nicole Pritts, Mark A Griswold and 4 more

Registry-linked trialAbstract read
In one paragraph

Article in Radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07201025 (Imaging Assessments of ARPKD Kidney Disease Progression), which is not on this map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07201025 recruitingnot on this mapstarted 2024, after this paper: background citation

Imaging Assessments of ARPKD Kidney Disease Progression

TypeobservationalSponsorThe Cleveland ClinicRan2024 to 2029Enrolled60ConditionsAutosomal Recessive Polycystic Kidney Disease
3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. A MR Fingerprinting Development Kit for Quantitative 3D Brain Imaging.Journal of magnetic resonance imaging : JMRI · 2026
    Article
  3. Article
  4. Article
  5. Serial TEuropean radiology · 2026
    Article
  6. Article
  7. Navigator-gated free-breathing joint TMagma (New York, N.Y.) · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Polycystic Kidney Disease in Children: The Current Status and the Next Horizon.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Christina J MacAskillFrom the Departments of Radiology (C.J.M., S.F., J.R.P., N.P., M.A.G., D.M., C.A.F., Y.C.), Genetics and Genome Sciences (M.L.D.), Pediatrics (M.L.D., K.M.D., C.A.F.), and Biomedical Engineering (M.A.G., D.M., C.A.F.), Case Western Reserve University, 11100 Euclid Ave, Bowell Building, Room B131, Cleveland, OH 44106; Departments of Radiology (M.M.) and Pediatrics (K.M., K.K.), University Hospitals Cleveland Medical Center, Cleveland, Ohio; and Center for Pediatric Nephrology, Cleveland Clinic Children's Hospital, Cleveland, Ohio (A.P., K.M.D.).ORCID 0000-0003-0023-0044
Michael MarkleyFrom the Departments of Radiology (C.J.M., S.F., J.R.P., N.P., M.A.G., D.M., C.A.F., Y.C.), Genetics and Genome Sciences (M.L.D.), Pediatrics (M.L.D., K.M.D., C.A.F.), and Biomedical Engineering (M.A.G., D.M., C.A.F.), Case Western Reserve University, 11100 Euclid Ave, Bowell Building, Room B131, Cleveland, OH 44106; Departments of Radiology (M.M.) and Pediatrics (K.M., K.K.), University Hospitals Cleveland Medical Center, Cleveland, Ohio; and Center for Pediatric Nephrology, Cleveland Clinic Children's Hospital, Cleveland, Ohio (A.P., K.M.D.).ORCID 0000-0002-8710-4405
Susan FarrFrom the Departments of Radiology (C.J.M., S.F., J.R.P., N.P., M.A.G., D.M., C.A.F., Y.C.), Genetics and Genome Sciences (M.L.D.), Pediatrics (M.L.D., K.M.D., C.A.F.), and Biomedical Engineering (M.A.G., D.M., C.A.F.), Case Western Reserve University, 11100 Euclid Ave, Bowell Building, Room B131, Cleveland, OH 44106; Departments of Radiology (M.M.) and Pediatrics (K.M., K.K.), University Hospitals Cleveland Medical Center, Cleveland, Ohio; and Center for Pediatric Nephrology, Cleveland Clinic Children's Hospital, Cleveland, Ohio (A.P., K.M.D.).ORCID 0000-0001-7930-6341
Ashlee ParsonsFrom the Departments of Radiology (C.J.M., S.F., J.R.P., N.P., M.A.G., D.M., C.A.F., Y.C.), Genetics and Genome Sciences (M.L.D.), Pediatrics (M.L.D., K.M.D., C.A.F.), and Biomedical Engineering (M.A.G., D.M., C.A.F.), Case Western Reserve University, 11100 Euclid Ave, Bowell Building, Room B131, Cleveland, OH 44106; Departments of Radiology (M.M.) and Pediatrics (K.M., K.K.), University Hospitals Cleveland Medical Center, Cleveland, Ohio; and Center for Pediatric Nephrology, Cleveland Clinic Children's Hospital, Cleveland, Ohio (A.P., K.M.D.).ORCID 0000-0001-6859-3373
Jacob R PerinoFrom the Departments of Radiology (C.J.M., S.F., J.R.P., N.P., M.A.G., D.M., C.A.F., Y.C.), Genetics and Genome Sciences (M.L.D.), Pediatrics (M.L.D., K.M.D., C.A.F.), and Biomedical Engineering (M.A.G., D.M., C.A.F.), Case Western Reserve University, 11100 Euclid Ave, Bowell Building, Room B131, Cleveland, OH 44106; Departments of Radiology (M.M.) and Pediatrics (K.M., K.K.), University Hospitals Cleveland Medical Center, Cleveland, Ohio; and Center for Pediatric Nephrology, Cleveland Clinic Children's Hospital, Cleveland, Ohio (A.P., K.M.D.).ORCID 0000-0003-3958-5432
Kimberly McBennettFrom the Departments of Radiology (C.J.M., S.F., J.R.P., N.P., M.A.G., D.M., C.A.F., Y.C.), Genetics and Genome Sciences (M.L.D.), Pediatrics (M.L.D., K.M.D., C.A.F.), and Biomedical Engineering (M.A.G., D.M., C.A.F.), Case Western Reserve University, 11100 Euclid Ave, Bowell Building, Room B131, Cleveland, OH 44106; Departments of Radiology (M.M.) and Pediatrics (K.M., K.K.), University Hospitals Cleveland Medical Center, Cleveland, Ohio; and Center for Pediatric Nephrology, Cleveland Clinic Children's Hospital, Cleveland, Ohio (A.P., K.M.D.).ORCID 0000-0001-9642-3814
Katherine KutneyFrom the Departments of Radiology (C.J.M., S.F., J.R.P., N.P., M.A.G., D.M., C.A.F., Y.C.), Genetics and Genome Sciences (M.L.D.), Pediatrics (M.L.D., K.M.D., C.A.F.), and Biomedical Engineering (M.A.G., D.M., C.A.F.), Case Western Reserve University, 11100 Euclid Ave, Bowell Building, Room B131, Cleveland, OH 44106; Departments of Radiology (M.M.) and Pediatrics (K.M., K.K.), University Hospitals Cleveland Medical Center, Cleveland, Ohio; and Center for Pediatric Nephrology, Cleveland Clinic Children's Hospital, Cleveland, Ohio (A.P., K.M.D.).ORCID 0000-0002-2573-2131
Mitchell L DrummFrom the Departments of Radiology (C.J.M., S.F., J.R.P., N.P., M.A.G., D.M., C.A.F., Y.C.), Genetics and Genome Sciences (M.L.D.), Pediatrics (M.L.D., K.M.D., C.A.F.), and Biomedical Engineering (M.A.G., D.M., C.A.F.), Case Western Reserve University, 11100 Euclid Ave, Bowell Building, Room B131, Cleveland, OH 44106; Departments of Radiology (M.M.) and Pediatrics (K.M., K.K.), University Hospitals Cleveland Medical Center, Cleveland, Ohio; and Center for Pediatric Nephrology, Cleveland Clinic Children's Hospital, Cleveland, Ohio (A.P., K.M.D.).
Nicole PrittsFrom the Departments of Radiology (C.J.M., S.F., J.R.P., N.P., M.A.G., D.M., C.A.F., Y.C.), Genetics and Genome Sciences (M.L.D.), Pediatrics (M.L.D., K.M.D., C.A.F.), and Biomedical Engineering (M.A.G., D.M., C.A.F.), Case Western Reserve University, 11100 Euclid Ave, Bowell Building, Room B131, Cleveland, OH 44106; Departments of Radiology (M.M.) and Pediatrics (K.M., K.K.), University Hospitals Cleveland Medical Center, Cleveland, Ohio; and Center for Pediatric Nephrology, Cleveland Clinic Children's Hospital, Cleveland, Ohio (A.P., K.M.D.).ORCID 0000-0002-4732-4243
Mark A GriswoldFrom the Departments of Radiology (C.J.M., S.F., J.R.P., N.P., M.A.G., D.M., C.A.F., Y.C.), Genetics and Genome Sciences (M.L.D.), Pediatrics (M.L.D., K.M.D., C.A.F.), and Biomedical Engineering (M.A.G., D.M., C.A.F.), Case Western Reserve University, 11100 Euclid Ave, Bowell Building, Room B131, Cleveland, OH 44106; Departments of Radiology (M.M.) and Pediatrics (K.M., K.K.), University Hospitals Cleveland Medical Center, Cleveland, Ohio; and Center for Pediatric Nephrology, Cleveland Clinic Children's Hospital, Cleveland, Ohio (A.P., K.M.D.).ORCID 0000-0002-3011-6747
Dan MaFrom the Departments of Radiology (C.J.M., S.F., J.R.P., N.P., M.A.G., D.M., C.A.F., Y.C.), Genetics and Genome Sciences (M.L.D.), Pediatrics (M.L.D., K.M.D., C.A.F.), and Biomedical Engineering (M.A.G., D.M., C.A.F.), Case Western Reserve University, 11100 Euclid Ave, Bowell Building, Room B131, Cleveland, OH 44106; Departments of Radiology (M.M.) and Pediatrics (K.M., K.K.), University Hospitals Cleveland Medical Center, Cleveland, Ohio; and Center for Pediatric Nephrology, Cleveland Clinic Children's Hospital, Cleveland, Ohio (A.P., K.M.D.).ORCID 0000-0003-1664-9579
Katherine M DellFrom the Departments of Radiology (C.J.M., S.F., J.R.P., N.P., M.A.G., D.M., C.A.F., Y.C.), Genetics and Genome Sciences (M.L.D.), Pediatrics (M.L.D., K.M.D., C.A.F.), and Biomedical Engineering (M.A.G., D.M., C.A.F.), Case Western Reserve University, 11100 Euclid Ave, Bowell Building, Room B131, Cleveland, OH 44106; Departments of Radiology (M.M.) and Pediatrics (K.M., K.K.), University Hospitals Cleveland Medical Center, Cleveland, Ohio; and Center for Pediatric Nephrology, Cleveland Clinic Children's Hospital, Cleveland, Ohio (A.P., K.M.D.).ORCID 0000-0003-3880-6838
Chris A FlaskFrom the Departments of Radiology (C.J.M., S.F., J.R.P., N.P., M.A.G., D.M., C.A.F., Y.C.), Genetics and Genome Sciences (M.L.D.), Pediatrics (M.L.D., K.M.D., C.A.F.), and Biomedical Engineering (M.A.G., D.M., C.A.F.), Case Western Reserve University, 11100 Euclid Ave, Bowell Building, Room B131, Cleveland, OH 44106; Departments of Radiology (M.M.) and Pediatrics (K.M., K.K.), University Hospitals Cleveland Medical Center, Cleveland, Ohio; and Center for Pediatric Nephrology, Cleveland Clinic Children's Hospital, Cleveland, Ohio (A.P., K.M.D.).ORCID 0000-0002-1066-333X
Yong ChenFrom the Departments of Radiology (C.J.M., S.F., J.R.P., N.P., M.A.G., D.M., C.A.F., Y.C.), Genetics and Genome Sciences (M.L.D.), Pediatrics (M.L.D., K.M.D., C.A.F.), and Biomedical Engineering (M.A.G., D.M., C.A.F.), Case Western Reserve University, 11100 Euclid Ave, Bowell Building, Room B131, Cleveland, OH 44106; Departments of Radiology (M.M.) and Pediatrics (K.M., K.K.), University Hospitals Cleveland Medical Center, Cleveland, Ohio; and Center for Pediatric Nephrology, Cleveland Clinic Children's Hospital, Cleveland, Ohio (A.P., K.M.D.).ORCID 0000-0001-6183-2693

Funding

TUMOR METABOLISM PROGRAMP30CA043703 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI Amar Desai · 1987 to 2026
$142.3M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
The Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI AMITABH CHAK · 2015 to 2026
$15.6M
Imaging Assessments of ARPKD Kidney Disease ProgressionR01DK114425 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI KATHERINE MACRAE DELL, Christopher A Flask · 2019 to 2026
$2.8M
MRI Imaging Biomarkers of ARPKD Kidney and Liver DiseaseR01DK085099 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI DELL, KATHERINE MACRAE, FLASK, CHRISTOPHER A · 2011 to 2015
$1.6M
NCI NIH HHS P30 CA043703NIDDK NIH HHS P30 DK097948NIDDK NIH HHS R01 DK085099NIDDK NIH HHS R01 DK114425NIGMS NIH HHS T32 GM007250
6 · The paper itself

Abstract

Background MR fingerprinting (MRF) provides rapid and simultaneous quantification of multiple tissue parameters in a single scan. Purpose To evaluate a rapid kidney MRF technique at 3.0 T in phantoms, healthy volunteers, and patients. Materials and Methods A 15-second kidney MRF acquisition was designed with 12 acquisition segments, a range of low flip angles (5°-12°), multiple magnetization preparation schema (T1, T2, and fat suppression), and an undersampled spiral trajectory. This technique was first validated in vitro using standardized T1 and T2 phantoms. Kidney T1 and T2 maps were then obtained for 10 healthy adult volunteers (mean age ± standard deviation, 35 years ± 13; six men) and three pediatric patients with autosomal recessive polycystic kidney disease (ARPKD) (mean age, 10 years ± 3; two boys) between August 2019 and October 2020 to evaluate the method in vivo. Results Results in nine phantoms showed good agreement with spin-echo-based T1 and T2 values (

Indexed as

AdultBreath HoldingChildFemaleHealthy VolunteersHumansImage Processing, Computer-AssistedKidneyMagnetic Resonance ImagingMalePhantoms, ImagingPolycystic Kidney, Autosomal Recessive

Identifiers

PMID34100680
PMCPMC8328087

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.