Evidence map›Paper›PMID 34100603›Full record

ArticleACS chemical neuroscience2021

Guanidine Derivatives: How Simple Structural Modification of Histamine H

Marek Staszewski, Dominik Nelic, Jakub Jończyk, Mariam Dubiel, Annika Frank, Holger Stark, Marek Bajda, Jan Jakubik, Krzysztof Walczyński

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Guanidines: Synthesis of Novel Histamine HPharmaceuticals (Basel, Switzerland) · 2023
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marek StaszewskiDepartment of Synthesis and Technology of Drugs, Medical University of Lodz, ul. Muszyńskiego 1, 90-151 Łódź, Poland.ORCID 0000-0003-2783-522X
Dominik NelicDepartment of Neurochemistry, Institute of Physiology CAS, Videnska 1083, CZ142 20, Prague, Czech Republic.
Jakub JończykDepartment of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.
Mariam DubielInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr. 1, Duesseldorf 40225, Germany.
Annika FrankInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr. 1, Duesseldorf 40225, Germany.
Holger StarkInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr. 1, Duesseldorf 40225, Germany.ORCID 0000-0003-3336-1710
Marek BajdaDepartment of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.ORCID 0000-0001-6032-0354
Jan JakubikDepartment of Neurochemistry, Institute of Physiology CAS, Videnska 1083, CZ142 20, Prague, Czech Republic.ORCID 0000-0002-1737-1487
Krzysztof WalczyńskiDepartment of Synthesis and Technology of Drugs, Medical University of Lodz, ul. Muszyńskiego 1, 90-151 Łódź, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article describes the discovery of novel potent muscarinic receptor antagonists identified during a search for more active histamine H

Indexed as

Histamine H3 AntagonistsReceptors, Histamine H3Cholinergic AgentsGuanidinesHistamineHistamine AntagonistsHumansMuscarinic AntagonistsStructure-Activity RelationshipCholinergic AgentsGuanidinesHistamineHistamine AntagonistsHistamine H3 AntagonistsMuscarinic AntagonistsReceptors, Histamine H3Antagonistsguanidine derivativeshistamine H3 receptormuscarinic M2 receptormuscarinic M4 receptorstructure−activity relationships

Identifiers

PMID34100603
PMCPMC8291587

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.