Evidence map›Paper›PMID 34100401›Full record

SynthesisIndian journal of pharmacology

Current status of

Hardeep Kaur, Phulen Sarma, Manpreet Kaur, Manisha, Anusuya Bhattacharya, Manisha Prajapat, Subodh Kumar, Ashutosh Singh, Rahul Singh, Harish Kumar and 3 more

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Indian journal of pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hardeep KaurDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Rishikesh, Uttarakhand, India.
Phulen SarmaDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Rishikesh, Uttarakhand, India.
Manpreet KaurDepartment of Nursing, AIIMS, Rishikesh, Uttarakhand, India.
ManishaDepartment of Nursing, AIIMS, Rishikesh, Uttarakhand, India.
Anusuya BhattacharyaDepartment of Ophthalmology, GMCH-32, Chandigarh, Rishikesh, Uttarakhand, India.
Manisha PrajapatDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Rishikesh, Uttarakhand, India.
Subodh KumarDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Rishikesh, Uttarakhand, India.
Ashutosh SinghDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Rishikesh, Uttarakhand, India.
Rahul SinghDepartment of Gastroenterology, Postgraduate Institute of Medical Education and Research, Rishikesh, Uttarakhand, India.
Harish KumarDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Rishikesh, Uttarakhand, India.
Prasad ThotaDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Rishikesh, Uttarakhand, India.
Ajay PrakashDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Rishikesh, Uttarakhand, India.
Bikash MedhiDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Rishikesh, Uttarakhand, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRegistration of study protocols brings about transparency and traceability and the amount of publication bias can be estimated. In this study, we have collected and presented data regarding clinical study registries, preclinical, in vitro and in silico study registries across the globe. MATERIALS AND

methodsWe searched via Google Search Engine with appropriate keywords e.g. name of country (n = 198), name of continent (n = 7), registry, study registry, animal, in silico, virtual, simulation, preclinical, animal, clinical trial. The overall pooled prevalence of clinical study registries and WHO primary registries in per continent was calculated using Medcalc software.

resultsThe overall pooled prevalence of clinical study registries were 13% in each continent. The prevalence of WHO primary study registries were 8.9% of the countries per continent. Overall, there are 17 primary registries associated with WHO ICTRP as primary registries, 2 partner registries and 6 registries are affiliated to ICMJE. However, the amount of preclinical animal study registry was quite less (n = 4). Regarding in vitro studies, only country specific in vitro fertilization registries were available, however, in other research domains, registries were absent. Only one simulation study registry was available.

conclusionAt priori study registration is essential to deal with selective reporting. Comparison between study protocol and final report allows us to know the protocol deviations and allows us to evaluate risk of bias and internal validity of the research findings. Although trialists are responsible for the completeness of records, yet the registries must have some measures for their periodic update and quality control of the data.

Indexed as

Clinical Trials as TopicRegistriesAnimalsClinical ProtocolsDrug Evaluation, PreclinicalHumansWorld Health Organizationclinical studyin silicopreclinicalStudy registry

Identifiers

PMID34100401
PMCPMC8265419

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.