Evidence map›Paper›PMID 34100394›Full record

ArticleIndian journal of pharmacology

Prediction of pharmacokinetic values of two various dosages of caffeine in premature neonates with apnea.

Fatemeh Faramarzi, Mohammadreza Shiran, Mohammadreza Rafati, Roya Farhadi, Ebrahim Salehifar, Maryam Nakhshab

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PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Fatemeh FaramarziClinical Pharmacy Research Center, Iran University of Medical Sciences, Tehran, Iran.
Mohammadreza ShiranImmunogenetics Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Mohammadreza RafatiDepartment of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Roya FarhadiDepartment of Pediatrics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Ebrahim SalehifarDepartment of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Maryam NakhshabDepartment of Pediatrics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Mazandaran University of Medical Sciences · IRIran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDespite extensive caffeine use in preterm infants, the pharmacokinetics (PKs) data are limited because of the studies are complicated to do in these patients. This research was investigated the PK profile of two various dosages of caffeine in premature neonates. MATERIALS AND

methodsThe PK values of caffeine in premature neonates with Apnea were predicted by using all of computer-based simulation (Simcyp

resultsIn the present study, the means CL, volume of distribution, and T1/2 of caffeine in preterm infants were 0.0476 L. h

conclusionsThere was overall good agreement between predicted and measured PK values in our study. This study provides an initial demonstration of Simcyp simulation advantage on anticipating of PK parameters.

Indexed as

ApneaCaffeineFemaleHumansInfantInfant, NewbornInfant, PrematureMaleModels, BiologicalCaffeineApneacaffeinepharmacokineticpremature neonates

Identifiers

PMID34100394
PMCPMC8265417
OpenAlexW3164563238

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.