Evidence map›Paper›PMID 34100297›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2022

The timed 25-foot walk in a large cohort of multiple sclerosis patients.

Anissa Kalinowski, Gary Cutter, Nina Bozinov, Jessica A Hinman, Michael Hittle, Robert Motl, Michelle Odden, Lorene M Nelson

Abstract read
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In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anissa KalinowskiDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.ORCID 0000-0003-3298-5580
Gary CutterSchool of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Nina BozinovDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.ORCID 0000-0002-7886-9756
Jessica A HinmanDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.ORCID 0000-0003-4590-1083
Michael HittleDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.ORCID 0000-0002-4934-2453
Robert MotlDepartment of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-5894-2290
Michelle OddenDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.ORCID 0000-0002-5974-3648
Lorene M NelsonDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.

Funding

Stanford BSSR Pre-Doctoral Training Program at the Intersection of Data Sciences with Behavioral, Social, and Population Health ResearchT32HL151323 · NHLBI · STANFORD UNIVERSITY · PI Michelle Christina Odden, David H Rehkopf · 2020 to 2026
$1.6M
NHLBI NIH HHS T32 HL151323
6 · The paper itself

Abstract

backgroundThe timed 25-foot walk (T25FW) is a key clinical outcome measure in multiple sclerosis patient management and clinical research.

objectivesTo evaluate T25FW performance and factors associated with its change in the Multiple Sclerosis Outcome Assessments Consortium (MSOAC) Placebo Database (

methodsWe created confirmed disability progression (CDP) variables for T25FW and Expanded Disability Status Scale (EDSS) outcomes. We used intraclass correlation coefficients (ICCs) and Bland Altman plots to evaluate reliability. We evaluated T25FW changes and predictive validity using a mixed-effects model, survival analysis, and nested case-control analysis.

resultsThe mean baseline score for the T25FW in this study population was 9.2 seconds, median = 6.1 (standard deviation = 11.0, interquartile range (IQR) = 4.8, 9.0). The T25FW measure demonstrated excellent test-retest reliability (ICC = 0.98). Walk times increased with age, disability, disease type, and disease duration; relapses were not associated with an increase. Patients with T25FW progression had a faster time to EDSS-CDP compared to those without (hazards ratio (HR): 2.6; confidence interval (CI): 2.2, 3.1). Changes in the T25FW were more likely to precede changes in EDSS.

conclusionThis research confirms the association of the T25FW with disability and provides some evidence of predictive validity. Our findings support the continued use of the T25FW in clinical practice and clinical trials.

Indexed as

Multiple SclerosisCohort StudiesDisability EvaluationHumansReproducibility of ResultsWalkingannual changebenchmarkingclinical trialdisease progressionExpanded Disability Status ScaleMultiple sclerosisMultiple Sclerosis Outcomes Assessment Consortiumnatural historypredictive validitytimed 25-foot walk)walking

Identifiers

PMID34100297
PMCPMC8795230

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.