Evidence map›Paper›PMID 34100181›Full record

ArticleNeurocritical care2021

Spinal Cord Perfusion Pressure Correlates with Anal Sphincter Function in a Cohort of Patients with Acute, Severe Traumatic Spinal Cord Injuries.

Florence R A Hogg, Siobhan Kearney, Mathew J Gallagher, Argyro Zoumprouli, Marios C Papadopoulos, Samira Saadoun

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurocritical care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Florence R A HoggAcademic Neurosurgery Unit, MCS Institute, St. George's, University of London, London, SW17 0RE, UK.
Siobhan KearneyAcademic Neurosurgery Unit, MCS Institute, St. George's, University of London, London, SW17 0RE, UK.
Mathew J GallagherAcademic Neurosurgery Unit, MCS Institute, St. George's, University of London, London, SW17 0RE, UK.
Argyro ZoumprouliNeuroanaesthesia Department and Neuro Intensive Care Unit, St. George's Hospital, London, UK.
Marios C Papadopoulos *Academic Neurosurgery Unit, MCS Institute, St. George's, University of London, London, SW17 0RE, UK.
Samira Saadoun *Academic Neurosurgery Unit, MCS Institute, St. George's, University of London, London, SW17 0RE, UK. ssaadoun@sgul.ac.uk.ORCID 0000-0002-5480-5678
St George's, University of London · GBSt George's Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute, severe traumatic spinal cord injury often causes fecal incontinence. Currently, there are no treatments to improve anal function after traumatic spinal cord injury. Our study aims to determine whether, after traumatic spinal cord injury, anal function can be improved by interventions in the neuro-intensive care unit to alter the spinal cord perfusion pressure at the injury site.

methodsWe recruited a cohort of patients with acute, severe traumatic spinal cord injuries (American Spinal Injury Association Impairment Scale grades A-C). They underwent surgical fixation within 72 h of the injury and insertion of an intrathecal pressure probe at the injury site to monitor intraspinal pressure and compute spinal cord perfusion pressure as mean arterial pressure minus intraspinal pressure. Injury-site monitoring was performed at the neuro-intensive care unit for up to a week after injury. During monitoring, anorectal manometry was also conducted over a range of spinal cord perfusion pressures.

resultsData were collected from 14 patients with consecutive traumatic spinal cord injury aged 22-67 years. The mean resting anal pressure was 44 cmH

conclusionsOur data indicate that spinal cord injury causes severe disruption of anal sphincter function. Several key components of anal continence (resting anal pressure, recto-anal inhibitory reflex, and anal pressure during cough and squeeze) markedly improve at higher spinal cord perfusion pressure. Maintaining too high of spinal cord perfusion pressure may worsen anal continence.

Indexed as

Fecal IncontinenceSpinal Cord InjuriesAdultAgedAnal CanalHumansMiddle AgedPerfusionYoung AdultAnal manometryAnal sphincterBlood pressureSpinal cord injurySpinal cord perfusion pressure

Identifiers

PMID34100181
PMCPMC8692299
OpenAlexW3167001837

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.