Evidence map›Paper›PMID 34100152›Full record

ArticleMolecular biology reports2021

The pleiotropic effects of Prunus avium L. extract against oxidative stress on human fibroblasts. An in vitro approach.

Sophia Letsiou, Aggeliki Karamaouna, Ioannis Ganopoulos, Aliki Kapazoglou, Aliki Xanthopoulou, Eirini Sarrou, Georgia Tanou, Athanasios Molassiotis

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Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sophia LetsiouInstitute of Plant Breeding and Genetic Resources, ELGO-Dimitra (ex NAGREF), 57001, Thessaloniki, Greece. sletsiou@gmail.com.ORCID http://orcid.org/0000-0002-9155-0889
Aggeliki KaramaounaInstitute of Plant Breeding and Genetic Resources, ELGO-Dimitra (ex NAGREF), 57001, Thessaloniki, Greece.
Ioannis GanopoulosLaboratory of Pomology, Department of Agriculture, Aristotle University of Thessaloniki, 57001, Thessaloniki, Greece.
Aliki KapazoglouHellenic Agricultural Organization-Demeter (HAO-Demeter), Institute of Olive Tree, Subtropical Crops and Viticulture (IOSV), Department of Vitis, Lykovrysi, 14123, Athens, Greece.
Aliki XanthopoulouInstitute of Plant Breeding and Genetic Resources, ELGO-Dimitra (ex NAGREF), 57001, Thessaloniki, Greece.
Eirini SarrouLaboratory of Pomology, Department of Agriculture, Aristotle University of Thessaloniki, 57001, Thessaloniki, Greece.
Georgia TanouInstitute of Soil Science and Water Resources, Hellenic Agricultural Organization-Demeter, Thermi, 57001, Thessaloniki, Greece.
Athanasios MolassiotisInstitute of Plant Breeding and Genetic Resources, ELGO-Dimitra (ex NAGREF), 57001, Thessaloniki, Greece.
Aristotle University of Thessaloniki · GRFederation of Greek Mariculture · GR

Funding

Foundation for Research and Technology-Hellas 148
6 · The paper itself

Abstract

There is a persistent interest in innovative and multifunctional ingredients in biology research. With regards to this, natural sources have an important role due to their multiple benefits. Thus, this study aims to present the pleiotropic activity of Prunus avium L. extract on human primary fibroblasts for proving its efficacy in dermis-related processes. We focused on the safety and efficacy assessments based on cytotoxicity and gene expression analysis under oxidative stress. Specifically, Prunus avium L. extract was proved non-cytotoxic in human fibroblasts. The gene expression analysis unveiled that this extract has in vitro protective properties on human dermal fibroblasts under oxidative stress related to antioxidant activity, anti-inflammatory response, cell proliferation and cell- aging. Our study demonstrated for the very first time that the Prunus avium L. extract is a multifunctional ingredient as it mediates several human dermis-related in vitro processes highlighting its potential to be used as an active ingredient in skin care products.

Indexed as

AntioxidantsCell LineCell ProliferationCell SurvivalCellular SenescenceFibroblastsFruitGene ExpressionHumansHydrogen PeroxideOxidative StressPlant ExtractsPrunus aviumSkinSkin CareAntioxidantsHydrogen PeroxidePlant ExtractsAntioxidantDermal fibroblastsIn vitroNatural extractSkin biologySweet cherry

Identifiers

PMID34100152
OpenAlexW3167100267

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.