Evidence map›Paper›PMID 34100007›Full record

Observational studyThe Lancet. Microbe2021

Detection of

Mulugeta Belay, Begna Tulu, Sidra Younis, David A Jolliffe, Dawit Tayachew, Hana Manwandu, Tenagnework Abozen, Emawayish A Tirfie, Metasebia Tegegn, Aboma Zewude and 19 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Lancet. Microbe, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 62 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Detection ofThe European respiratory journal · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Observational
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors at 14 institutions in 8 countries.

Mulugeta BelayBarts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Begna TuluAklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.
Sidra YounisBarts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
David A JolliffeBarts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Dawit TayachewArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Hana ManwanduArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Tenagnework AbozenArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Emawayish A TirfieArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Metasebia TegegnArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Aboma ZewudeAklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.
Sally ForrestDepartment of Medicine, University of Cambridge, Cambridge, UK.
Jonathan MayitoSchool of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda.
Jim F HuggettNational Measurement Laboratory, LGC, Teddington, Middlesex, UK.
Gerwyn M JonesNational Measurement Laboratory, LGC, Teddington, Middlesex, UK.
Denise M O'SullivanNational Measurement Laboratory, LGC, Teddington, Middlesex, UK.
Henny M MartineauDepartment of Pathology, The Royal Veterinary College, Hatfield, UK.
Mahdad NoursadeghiDivision of Infection and Immunity, University College London, London, UK.
Aneesh ChandranDivision of Infection and Immunity, University College London, London, UK.
Kathryn A HarrisCamelia Botnar Laboratories, Great Ormond Street Hospital for Children, London, UK.
Vlad NikolayevskyyNational Mycobacterium Reference Service-South, National Infection Service, London, UK.
Julie DemaretInstitut d'Immunologie, Centre de Biologie-Pathologie-Génétique du CHRU de Lille, Lille, France.
Stefan BergAnimal and Plant Health Agency, New Haw, UK.
Martin VordermeierAnimal and Plant Health Agency, New Haw, UK.
Taye T BalchaClinical Infection Medicine, Department of Translational Medicine, Lund University, Malmö, Sweden.
Abraham AseffaArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Gobena AmeniAklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.
Markos AbebeArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Stephen T ReeceDepartment of Medicine, University of Cambridge, Cambridge, UK.
Adrian R MartineauBarts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Armauer Hansen Research Institute · ETAddis Ababa University · ETQueen Mary University of London · GBAnimal and Plant Health Agency · GBNational Physical Laboratory · GBUniversity College London · GBUniversity of Cambridge · GBCentre Hospitalier Universitaire de Lille · FRGreat Ormond Street Hospital · GBLund University · SEMakerere University · UGNational University of Medical Sciences · PKRoyal Veterinary College · GBUniversity of Surrey · GB

Funding

Ethiopia-Emory TB Research Training ProgramD43TW009127 · FIC · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Kidist Bobosha · 2013 to 2026
$3.4M
Cancer Research UKFIC NIH HHS D43 TW009127Medical Research Council MR/P024548/1Wellcome Trust 207511/Z/17/Z
6 · The paper itself

Abstract

backgroundHaematopoietic stem cells expressing the CD34 surface marker have been posited as a niche for

methodsWe did a cross-sectional study in Ethiopia between Nov 22, 2017, and Jan 10, 2019. Digital PCR (dPCR) was used to determine whether

findingsValid dPCR data (ie, droplet counts >10 000 per well) were available for paired CD34-positive and CD34-negative PBMC fractions from 197 (70%) of 284 participants who contributed data to cross-sectional analyses.

interpretationWe report a novel molecular microbiological biomarker of latent tuberculosis infection with properties that are distinct from those of a commercial interferon-γ release assay. Our findings implicate the bone marrow as a niche for

fundingUK Medical Research Council.

Indexed as

HIV InfectionsLatent TuberculosisMycobacterium tuberculosisTuberculosisCross-Sectional StudiesDNAEthiopiaHumansIsoniazidLeukocytes, MononuclearProspective StudiesTuberculin TestDNAIsoniazid

Identifiers

PMID34100007
PMCPMC8172384
OpenAlexW3145876172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.